Apo(a) and Defensin in Cerebral Arteries: Individuals With No Clinical Evidence of Atherosclerosis
| Patient No. . | Age (yr)/Sex . | Race . | AS Risk . | Systemic AS . | CAS . | CApo(a) . | DEF . |
|---|---|---|---|---|---|---|---|
| 1 | 25/M | C | CAD-none | 0 | − | + | |
| Aorta-mild | |||||||
| 2 | 52/F | C | CAD-none | 0 | − | + | |
| Aorta-none | |||||||
| 3 | 32/F | C | CAD-none | 1 | + | + | |
| Aorta-none | |||||||
| 4 | 65/F | C | CAD-min | 1 | + | + | |
| Aorta-none | |||||||
| 5 | 40/M | C | HTN | CAD-none | 1 | + | ++ |
| Aorta-min | |||||||
| 6 | 46/M | AA | HTN | CAD-mild | 1 | + | + |
| Aorta-mild | |||||||
| 7 | 42/F | C | CAD-none | 1 | + | + | |
| Aorta-none | |||||||
| 8 | 56/M | A | cig | CAD-none | 1 | + | ++ |
| Aorta-mild | |||||||
| 9 | 62/M | C | cig, DM, lipids | CAD-mod | 1 | + | ++ |
| Aorta-mod | |||||||
| 10 | 30/F | C | DM | CAD-mild | 1 | ++ | + |
| Aorta-mild | |||||||
| 11 | 67/M | AA | cig | CAD-mod | 2 | + | ++ |
| Aorta-mod | |||||||
| 12 | 65/M | AA | XRT | CAD-mild | 2 | ++ | +++ |
| Aorta-mild | |||||||
| 13 | 55/M | C | CAD-mild | 2 | ++ | +++ | |
| Aorta-min | |||||||
| 14 | 53/F | C | lipids | CAD-mild | 2 | ++ | ++ |
| Aorta-mild | |||||||
| 15 | 67/M | C | CAD-mod | 3 | +++ | +++ | |
| Aorta-mod | |||||||
| 16 | 81/F | AA | CAD-min | 4 | +++ | +++ | |
| Aorta-min | |||||||
| 17 | 29/F | C | CAD-none | 1 | − | + | |
| Aorta-none | |||||||
| 18 | 65/M | C | cig | CAD-mod | 3 | +++ | +++ |
| Aorta-mod | |||||||
| 19 | 80/M | C | CAD-min | 3 | ++ | + | |
| Aorta-min | |||||||
| 20 | 51/M | C | CAD-mild | 2 | ++ | ++ | |
| Aorta-mild | |||||||
| 21 | 55/F | C | cig | CAD-mild | 3 | +++ | +++ |
| Aorta-mod |
| Patient No. . | Age (yr)/Sex . | Race . | AS Risk . | Systemic AS . | CAS . | CApo(a) . | DEF . |
|---|---|---|---|---|---|---|---|
| 1 | 25/M | C | CAD-none | 0 | − | + | |
| Aorta-mild | |||||||
| 2 | 52/F | C | CAD-none | 0 | − | + | |
| Aorta-none | |||||||
| 3 | 32/F | C | CAD-none | 1 | + | + | |
| Aorta-none | |||||||
| 4 | 65/F | C | CAD-min | 1 | + | + | |
| Aorta-none | |||||||
| 5 | 40/M | C | HTN | CAD-none | 1 | + | ++ |
| Aorta-min | |||||||
| 6 | 46/M | AA | HTN | CAD-mild | 1 | + | + |
| Aorta-mild | |||||||
| 7 | 42/F | C | CAD-none | 1 | + | + | |
| Aorta-none | |||||||
| 8 | 56/M | A | cig | CAD-none | 1 | + | ++ |
| Aorta-mild | |||||||
| 9 | 62/M | C | cig, DM, lipids | CAD-mod | 1 | + | ++ |
| Aorta-mod | |||||||
| 10 | 30/F | C | DM | CAD-mild | 1 | ++ | + |
| Aorta-mild | |||||||
| 11 | 67/M | AA | cig | CAD-mod | 2 | + | ++ |
| Aorta-mod | |||||||
| 12 | 65/M | AA | XRT | CAD-mild | 2 | ++ | +++ |
| Aorta-mild | |||||||
| 13 | 55/M | C | CAD-mild | 2 | ++ | +++ | |
| Aorta-min | |||||||
| 14 | 53/F | C | lipids | CAD-mild | 2 | ++ | ++ |
| Aorta-mild | |||||||
| 15 | 67/M | C | CAD-mod | 3 | +++ | +++ | |
| Aorta-mod | |||||||
| 16 | 81/F | AA | CAD-min | 4 | +++ | +++ | |
| Aorta-min | |||||||
| 17 | 29/F | C | CAD-none | 1 | − | + | |
| Aorta-none | |||||||
| 18 | 65/M | C | cig | CAD-mod | 3 | +++ | +++ |
| Aorta-mod | |||||||
| 19 | 80/M | C | CAD-min | 3 | ++ | + | |
| Aorta-min | |||||||
| 20 | 51/M | C | CAD-mild | 2 | ++ | ++ | |
| Aorta-mild | |||||||
| 21 | 55/F | C | cig | CAD-mild | 3 | +++ | +++ |
| Aorta-mod |
Abbreviations: C, Caucasian; A, Asian; AA, African-American; unk, unknown race; DM, diabetes mellitus; HTN, hypertension; cig, cigarette use; lipids, lipid disorder of any type; XRT, whole brain irradiation; CA, coronary arteries; CAD, coronary artery disease; CApo(a), immunohistochemical deposition of cerebral apolipoprotein (a); −, no staining; +, focal rare endothelial cell staining in an atherosclerotic plaque or normal appearing vessel wall; ++, focal subendothelial cell staining ± endothelial staining in an atherosclerotic plaque; +++, diffuse extensive subendothelial cell staining in an atherosclerotic plaque; DEF, immunohistochemical deposition of defensin.