Table 2. Effects on Bone Marrow and... | American Society of Hematology

Table 2.

Effects on Bone Marrow and Spleen of FL Treatment Alone or in Combination With G-CSF

Site	Control	FL	G-CSF	FL + G-CSF
Marrow
Cells/femur (× 10⁶/femur)	27.6 ± 1.1	22.0 ± 3.2^*	19.6 ± 0.9^*	18.6 ± 2.1^*
GM-CFC/femur	18,000 ± 340	18,680 ± 413^*	3,200 ± 173^*	2,400 ± 120^*
BFU-E/femur	796 ± 412	396 ± 280^*	0	0
CFU-mix/femur	2,792 ± 1,312	2,264 ± 865	660 ± 245^*	0
CFU-S/femur	5,405 ± 62	4,700 ± 34^*	825 ± 13^*	450 ± 112^*
Spleen
Cells/spleen (× 10⁶/spleen)	128 ± 23	115 ± 16	178 ± 21^*	232 ± 59^*
GM-CFC/spleen	1,440 ± 321	1,880 ± 212^*	74,280 ± 816^*	257,580 ± 2,300^*
BFU-E/spleen	0	664 ± 54	1,464 ± 112	16,200 ± 1,800
CFU-mix/spleen	0	396 ± 68	12,796 ± 1,402	10,680 ± 888
CFU-S/spleen	7,458 ± 86	3,583 ± 321^*	17,050 ± 554^*	22,500 ± 4,590^*

Site	Control	FL	G-CSF	FL + G-CSF
Marrow
Cells/femur (× 10⁶/femur)	27.6 ± 1.1	22.0 ± 3.2^*	19.6 ± 0.9^*	18.6 ± 2.1^*
GM-CFC/femur	18,000 ± 340	18,680 ± 413^*	3,200 ± 173^*	2,400 ± 120^*
BFU-E/femur	796 ± 412	396 ± 280^*	0	0
CFU-mix/femur	2,792 ± 1,312	2,264 ± 865	660 ± 245^*	0
CFU-S/femur	5,405 ± 62	4,700 ± 34^*	825 ± 13^*	450 ± 112^*
Spleen
Cells/spleen (× 10⁶/spleen)	128 ± 23	115 ± 16	178 ± 21^*	232 ± 59^*
GM-CFC/spleen	1,440 ± 321	1,880 ± 212^*	74,280 ± 816^*	257,580 ± 2,300^*
BFU-E/spleen	0	664 ± 54	1,464 ± 112	16,200 ± 1,800
CFU-mix/spleen	0	396 ± 68	12,796 ± 1,402	10,680 ± 888
CFU-S/spleen	7,458 ± 86	3,583 ± 321^*	17,050 ± 554^*	22,500 ± 4,590^*

Data presented are the mean of 2 experiments ± 1 SD, each from 5 donors.

P < .005 v control.