Expression of BCL-2 Oncoprotein in Leukemic Cells From Children With Newly Diagnosed ALL
| Patient Subset . | N . | BCL-2 Level (U/blast) . | P Value . | ||
|---|---|---|---|---|---|
| . | . | Mean (SE) . | Median . | Range . | . |
| All | 338 | 67.6 (2.4) | 65.0 | 0.0-221.0 | — |
| Female | 140 | 65.6 (3.7) | 64.5 | 0.0-210.0 | |
| Male | 198 | 68.7 (3.1) | 65.0 | 0.0-221.0 | NS |
| Age <10 yr | 261 | 68.6 (2.8) | 68.0 | 0.0-221.0 | |
| Age ≥10 yr | 77 | 63.4 (4.8) | 59.0 | 0.0-196.0 | NS |
| WBC <50 × 109/L | 237 | 71.6 (2.8) | 70.0 | 0.0-221.0 | |
| WBC ≥50 ×109/L | 101 | 57.7 (4.3) | 44.0 | 0.0-180.0 | .008 |
| NCI standard risk | 183 | 71.7 (3.2) | 73.0 | 1.0-221.0 | |
| NCI poor risk | 155 | 62.4 (3.6) | 55.0 | 0.0-196.0 | .053 |
| Without lymphadenopathy | 166 | 71.6 (3.5) | 73.5 | 0.0-210.0 | |
| With lymphadenopathy | 172 | 63.4 (3.3) | 59.0 | 0.0-221.0 | .088 |
| Without splenomegaly | 158 | 75.1 (3.8) | 72.0 | 0.0-221.0 | |
| With splenomegaly | 179 | 60.5 (3.0) | 56.0 | 0.0-171.0 | .001 |
| Without hepatomegaly | 159 | 72.4 (3.6) | 70.0 | 0.0-210.0 | |
| With hepatomegaly | 178 | 62.9 (3.1) | 59.8 | 0.0-221.0 | .049 |
| Without mediastinal mass | 295 | 69.9 (2.5) | 70.0 | 0.0-221.0 | |
| With mediastinal mass | 43 | 50.4 (6.7) | 41.0 | 0.0-196.0 | .006 |
| B-lineage ALL | 286 | 72.5 (2.6) | 73.0 | 0.0-221.0 | |
| T-lineage ALL | 52 | 40.3 (5.0) | 33.3 | 0.0-196.0 | <.001 |
| PCR-ALL | 191 | 70.2 (3.2) | 66.8 | 0.0-210.0 | |
| MLL-AF-4+ ALL | 4 | 61.4 (20.5) | 64.0 | 16.0-101.5 | NS |
| E2A-PBX-1+ ALL | 11 | 37.3 (8.5) | 24.0 | 9.0-89.0 | .022 |
| BCR-ABL+ ALL | 10 | 56.7 (13.9) | 50.5 | 5.0-125.0 | NS |
| No leukemic cell growth in SCID mice | 232 | 70.1 (2.7) | 69.5 | 0.0-200.0 | |
| Leukemic cell growth in SCID mice | 63 | 57.4 (5.4) | 46.0 | 4.0-210.0 | .035 |
| RER (day 7 BM) | 246 | 68.1 (2.4) | 67.0 | 0.0-221.0 | |
| SER (day 7 BM) | 78 | 66.9 (4.9) | 60.8 | 0.0-200.0 | NS |
| T-lineage ALL, RER | 35 | 32.8 (4.8) | 25.5 | 0.0-102.0 | |
| T-lineage ALL, SER | 14 | 61.9 (12.7) | 59.3 | 0.0-196.0 | .011 |
| B-lineage ALL, RER | 211 | 73.9 (2.5) | 72.0 | 0.0-221.0 | |
| B-lineage ALL, SER | 64 | 68.0 (2.4) | 63.0 | 0.0-200.0 | NS |
| CR (day 28 BM) | 329 | 67.6 (2.4) | 65.0 | 0.0-221.0 | |
| No CR (day 28 BM) | 7 | 72.7 (8.2) | 65.0 | 54.0-117.0 | NS |
| Patient Subset . | N . | BCL-2 Level (U/blast) . | P Value . | ||
|---|---|---|---|---|---|
| . | . | Mean (SE) . | Median . | Range . | . |
| All | 338 | 67.6 (2.4) | 65.0 | 0.0-221.0 | — |
| Female | 140 | 65.6 (3.7) | 64.5 | 0.0-210.0 | |
| Male | 198 | 68.7 (3.1) | 65.0 | 0.0-221.0 | NS |
| Age <10 yr | 261 | 68.6 (2.8) | 68.0 | 0.0-221.0 | |
| Age ≥10 yr | 77 | 63.4 (4.8) | 59.0 | 0.0-196.0 | NS |
| WBC <50 × 109/L | 237 | 71.6 (2.8) | 70.0 | 0.0-221.0 | |
| WBC ≥50 ×109/L | 101 | 57.7 (4.3) | 44.0 | 0.0-180.0 | .008 |
| NCI standard risk | 183 | 71.7 (3.2) | 73.0 | 1.0-221.0 | |
| NCI poor risk | 155 | 62.4 (3.6) | 55.0 | 0.0-196.0 | .053 |
| Without lymphadenopathy | 166 | 71.6 (3.5) | 73.5 | 0.0-210.0 | |
| With lymphadenopathy | 172 | 63.4 (3.3) | 59.0 | 0.0-221.0 | .088 |
| Without splenomegaly | 158 | 75.1 (3.8) | 72.0 | 0.0-221.0 | |
| With splenomegaly | 179 | 60.5 (3.0) | 56.0 | 0.0-171.0 | .001 |
| Without hepatomegaly | 159 | 72.4 (3.6) | 70.0 | 0.0-210.0 | |
| With hepatomegaly | 178 | 62.9 (3.1) | 59.8 | 0.0-221.0 | .049 |
| Without mediastinal mass | 295 | 69.9 (2.5) | 70.0 | 0.0-221.0 | |
| With mediastinal mass | 43 | 50.4 (6.7) | 41.0 | 0.0-196.0 | .006 |
| B-lineage ALL | 286 | 72.5 (2.6) | 73.0 | 0.0-221.0 | |
| T-lineage ALL | 52 | 40.3 (5.0) | 33.3 | 0.0-196.0 | <.001 |
| PCR-ALL | 191 | 70.2 (3.2) | 66.8 | 0.0-210.0 | |
| MLL-AF-4+ ALL | 4 | 61.4 (20.5) | 64.0 | 16.0-101.5 | NS |
| E2A-PBX-1+ ALL | 11 | 37.3 (8.5) | 24.0 | 9.0-89.0 | .022 |
| BCR-ABL+ ALL | 10 | 56.7 (13.9) | 50.5 | 5.0-125.0 | NS |
| No leukemic cell growth in SCID mice | 232 | 70.1 (2.7) | 69.5 | 0.0-200.0 | |
| Leukemic cell growth in SCID mice | 63 | 57.4 (5.4) | 46.0 | 4.0-210.0 | .035 |
| RER (day 7 BM) | 246 | 68.1 (2.4) | 67.0 | 0.0-221.0 | |
| SER (day 7 BM) | 78 | 66.9 (4.9) | 60.8 | 0.0-200.0 | NS |
| T-lineage ALL, RER | 35 | 32.8 (4.8) | 25.5 | 0.0-102.0 | |
| T-lineage ALL, SER | 14 | 61.9 (12.7) | 59.3 | 0.0-196.0 | .011 |
| B-lineage ALL, RER | 211 | 73.9 (2.5) | 72.0 | 0.0-221.0 | |
| B-lineage ALL, SER | 64 | 68.0 (2.4) | 63.0 | 0.0-200.0 | NS |
| CR (day 28 BM) | 329 | 67.6 (2.4) | 65.0 | 0.0-221.0 | |
| No CR (day 28 BM) | 7 | 72.7 (8.2) | 65.0 | 54.0-117.0 | NS |
Abbreviation: NS, not significant.