Table 1. Pathologic Assessment of... | American Society of Hematology

Table 1.

Pathologic Assessment of End-Organs After Guinea Pigs Received AT and/or LMWH 30 Minutes Postinfusion of DIC-SA

	Gross Hemorrhage	Abscess Formation	Mortality	Histopathology (fibrin formation)	Normal Histology
Saline controls (n = 5)	0^*	0	0	0^*	5^*
Non–DIC-SA controls (n = 5)	0^*	1	0	0^*	4^†
DIC-SA alone (n = 14)	14	5	5	14	0
DIC-SA + AT concentrate
125 IU/kg (n = 3)	3	1	0	3	0
250 IU/kg (n = 11)	1^*	2	0^‡	0^*	9^*
500 IU/kg (n = 4)	0^*	3	0	0	1
1,000 IU/kg (n = 7)	0^*	3	0	0^*	4^*
DIC-SA + LMWH (n = 4)	3	1	1	4	0
DIC-SA + LMWH + 125 IU/kg AT (n = 5)	5	3	1	0^*	0

	Gross Hemorrhage	Abscess Formation	Mortality	Histopathology (fibrin formation)	Normal Histology
Saline controls (n = 5)	0^*	0	0	0^*	5^*
Non–DIC-SA controls (n = 5)	0^*	1	0	0^*	4^†
DIC-SA alone (n = 14)	14	5	5	14	0
DIC-SA + AT concentrate
125 IU/kg (n = 3)	3	1	0	3	0
250 IU/kg (n = 11)	1^*	2	0^‡	0^*	9^*
500 IU/kg (n = 4)	0^*	3	0	0	1
1,000 IU/kg (n = 7)	0^*	3	0	0^*	4^*
DIC-SA + LMWH (n = 4)	3	1	1	4	0
DIC-SA + LMWH + 125 IU/kg AT (n = 5)	5	3	1	0^*	0

Significantly different from DIC-SA alone group (P ≤ .001).

Significantly different from DIC-SA alone group (P ≤ .01).

Significantly different from DIC-SA alone group (P ≤ .05).