Comparison of the Phenotypes of Family Members With Type I and Type III Protein S Deficiency
| Parameter . | Type I . | Type III . | P . |
|---|---|---|---|
| . | (n = 23) . | (n = 8) . | . |
| Age (yr) | 28 ± 13 | 55 ± 18 | .0001 |
| Total protein S antigen (nmol/L) | 184 ± 23 | 255 ± 33 | .0001 |
| Free protein S antigen (nmol/L) | 12 ± 6 | 10 ± 4 | .38 |
| C4bBP-β+ antigen (nmol/L) | 211 ± 38 | 270 ± 52 | .0092 |
| Parameter . | Type I . | Type III . | P . |
|---|---|---|---|
| . | (n = 23) . | (n = 8) . | . |
| Age (yr) | 28 ± 13 | 55 ± 18 | .0001 |
| Total protein S antigen (nmol/L) | 184 ± 23 | 255 ± 33 | .0001 |
| Free protein S antigen (nmol/L) | 12 ± 6 | 10 ± 4 | .38 |
| C4bBP-β+ antigen (nmol/L) | 211 ± 38 | 270 ± 52 | .0092 |
Values are the mean ± SD. Limits used for protein S deficiency subtype classification in this case were a total protein S antigen level ≤218 nmol/L (below the reference range) for type I and ≥219 nmol/L (within the reference range) for type III. All were carriers of the Gly295Val mutation. The P value was calculated using Student's t test and is a comparison of the 2 groups for that variable.