Alterations in the Distribution of Different Subclasses of Human CFC at Different Times After the Transplantation of Human Bone Marrow Cells into NOD/SCID Mice
| Time of Assessment (posttransplant) . | I . | II . | III . | IV . |
|---|---|---|---|---|
| . | E:mB:pB . | mGM:pGM . | pB:pGM:GEMM . | total B:total GM:GEMM . |
| SA | 40:26:34 | 86:14 | 79:19:2 | 64:36:0.6 |
| 2 days | 19:40:41 | 94:6 | 95:3:2 | 80:19:1 |
| 4-5 weeks | 27:38:35 | 90:10 | 41:56:3 | 17:83:0.4 |
| 7-10 weeks | 0:37:63 | 82:18 | 22:75:3 | 8:92:0.8 |
| 16 weeks | 0:71:29 | 92:8 | 27:60:13 | 11:87:0.2 |
| Time of Assessment (posttransplant) . | I . | II . | III . | IV . |
|---|---|---|---|---|
| . | E:mB:pB . | mGM:pGM . | pB:pGM:GEMM . | total B:total GM:GEMM . |
| SA | 40:26:34 | 86:14 | 79:19:2 | 64:36:0.6 |
| 2 days | 19:40:41 | 94:6 | 95:3:2 | 80:19:1 |
| 4-5 weeks | 27:38:35 | 90:10 | 41:56:3 | 17:83:0.4 |
| 7-10 weeks | 0:37:63 | 82:18 | 22:75:3 | 8:92:0.8 |
| 16 weeks | 0:71:29 | 92:8 | 27:60:13 | 11:87:0.2 |
Four types of comparisons are shown (I, II, III, IV). Column I shows the relative numbers of CFU-E (E), mature BFU-E (mB), and primitive BFU-E (pB) as a proportion of the total erythroid CFC population (E + mB + pB). Column II shows the ratio of mature (m) to primitive (p) CFU-GM (GM) in the total CFU-GM population detected. Column III shows the relative numbers of different types of primitive CFC, and column IV shows the relative numbers of all erythroid-restricted (E + B), granulopoietic-restricted (GM) and multilineage (GEMM) CFC as a fraction of the total human CFC population detected at each time point. CFC measurements are from the same 8 experiments shown in Fig 5. Criteria used for distinguishing primitive and mature subclasses of BFU-E and CFU-GM are given in Table 3.