Immunologic Features of Kindred No. 2
| . | Fas Mutation . | % CD4−CD8− . | CD19+ cells/ . | Fas-Mediated . |
|---|---|---|---|---|
| . | . | TCRα/β+ . | mm3 (%) . | Apoptosis . |
| . | . | . | . | % Cell Loss4-150 . |
| Patient no. 2 | + | 25 | 3485 (41) | 35 |
| Mother | + | 0.6 | 135 (6) | 25 |
| Maternal grandfather | + | 0.9 | 148 (7) | 17 |
| Maternal uncle no. 1 | + | 0.7 | 80 (4) | 37 |
| Father | − | 0.2 | 234 (10) | 90 |
| Sister | − | 0.8 | 51 (3) | ND |
| Maternal uncle no. 2 | − | 0.7 | 80 (4) | 62 |
| Maternal grandmother | − | 0.1 | 89 (6) | 63 |
| . | Fas Mutation . | % CD4−CD8− . | CD19+ cells/ . | Fas-Mediated . |
|---|---|---|---|---|
| . | . | TCRα/β+ . | mm3 (%) . | Apoptosis . |
| . | . | . | . | % Cell Loss4-150 . |
| Patient no. 2 | + | 25 | 3485 (41) | 35 |
| Mother | + | 0.6 | 135 (6) | 25 |
| Maternal grandfather | + | 0.9 | 148 (7) | 17 |
| Maternal uncle no. 1 | + | 0.7 | 80 (4) | 37 |
| Father | − | 0.2 | 234 (10) | 90 |
| Sister | − | 0.8 | 51 (3) | ND |
| Maternal uncle no. 2 | − | 0.7 | 80 (4) | 62 |
| Maternal grandmother | − | 0.1 | 89 (6) | 63 |
Abbreviation: ND, not done.
Percentage of lymphocytes undergoing apoptosis after exposure to the anti-Fas MoAb CH11.