Table 1. Percent Recovery of Peripheral... | American Society of Hematology

Table 1.

Percent Recovery of Peripheral Blood Lymphocyte Subsets During and After Intensive Chemotherapy

Timepoint	CD4⁺	CD8⁺	CD8⁺CD3⁺	B Cells	NK Cells
Pretherapy^*	100	100	100	100	100
Nadir^†	16 ± 3	27 ± 5^‡	26 ± 6	3 ± 2^‡	27 ± 25
3 mos	35 ± 7	98 ± 24^‡	113 ± 34^‡	164 ± 43^‡	86 ± 18^‡
6 mos	49 ± 9	89 ± 11^‡	94 ± 15^‡	197 ± 28^‡	94 ± 28
9 mos	48 ± 12	105 ± 23^‡	109 ± 29^‡	191 ± 41^‡	148 ± 71
12 mos	78 ± 19	85 ± 16	84 ± 16	124 ± 30	69 ± 15

Timepoint	CD4⁺	CD8⁺	CD8⁺CD3⁺	B Cells	NK Cells
Pretherapy^*	100	100	100	100	100
Nadir^†	16 ± 3	27 ± 5^‡	26 ± 6	3 ± 2^‡	27 ± 25
3 mos	35 ± 7	98 ± 24^‡	113 ± 34^‡	164 ± 43^‡	86 ± 18^‡
6 mos	49 ± 9	89 ± 11^‡	94 ± 15^‡	197 ± 28^‡	94 ± 28
9 mos	48 ± 12	105 ± 23^‡	109 ± 29^‡	191 ± 41^‡	148 ± 71
12 mos	78 ± 19	85 ± 16	84 ± 16	124 ± 30	69 ± 15

Mean pretherapy values (CD4⁺: 807 ± 152, CD8⁺: 641 ± 139, CD8⁺CD3⁺: 520 ± 123, B: 215 ± 50, NK: 262 ± 56 cells/μL) are arbitrarily designated as 100%. Percent change was calculated for individual patients by dividing the values obtained at each timepoint specified by the pretherapy value × 100. Mean percent change and SEM for all patients studied is shown.

†

Nadir is defined as the timepoint when the lowest counts for each individual subset was recorded. This generally occurred at or near the completion of chemotherapy.

‡

P < .05 when compared with percent change for CD4⁺ cells at the same timepoint using Wilcoxon Signed Rank Test.

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