Proliferation Indexes, Mean Mitotic Activity, p53 Overexpression, Ploidy Status, and bcl-1 Rearrangement in the Different Subtypes of MCL and in Common Versus Blastoid MCL Types
| MCL Subtype . | Proliferation Index (CI) . | Mean Mitotic Activity (CI) . | p53 Overexpressed . | Tetraploid Chromosome Numbers . | No. of Cases bcl-1 Rearranged . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | . | . | . | . |
| A.Different Subtypes of MCL | ||||||||||
| Common (n = 35) | 27% (±21.1%) | 21.26 (±15.4) | 2 (6%) | 2/26 (8%) | 14 (40%) | |||||
| Range, 5%-60% | Range, 2-71 | |||||||||
| Lymphoblastoid (n = 15) | 58% (±49.9%) | P > .1 | 57.33 (±37.3) | P > .1 | 4 (27%) | P > .1 | 5/14 (36%) | P < .032 | 8 (53%) | P > .1 |
| Range, 25%-80% | Range, 4-111 | |||||||||
| Pleomorphic (n = 14) | 53% (±39.9%) | 51.07 (±30.2) | 2 (14%) | 8/10 (80%) | 9 (64%) B.Common versus blastoid MCL types | |||||
| Range, 20%-90% | Range, 9-126 | |||||||||
| Common (n = 35) | 27% (±21.1%) | 21.26 (±15.4) | 2 (6%) | 2/26 (8%) | 14 (40%) | |||||
| Range, 5%-60% | Range, 2-71 | |||||||||
| Blastoid*(n = 29) | 55% (±48.3%) | P < .001 | 54.31 (±40.73) | P < .001 | 6 (21%) | P = .0713 | 13/24 (54%) | P = .0003 | 17 (59%) | P = .143 |
| Range, 20%-90% | Range, 4-126 | |||||||||
| MCL Subtype . | Proliferation Index (CI) . | Mean Mitotic Activity (CI) . | p53 Overexpressed . | Tetraploid Chromosome Numbers . | No. of Cases bcl-1 Rearranged . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | . | . | . | . |
| A.Different Subtypes of MCL | ||||||||||
| Common (n = 35) | 27% (±21.1%) | 21.26 (±15.4) | 2 (6%) | 2/26 (8%) | 14 (40%) | |||||
| Range, 5%-60% | Range, 2-71 | |||||||||
| Lymphoblastoid (n = 15) | 58% (±49.9%) | P > .1 | 57.33 (±37.3) | P > .1 | 4 (27%) | P > .1 | 5/14 (36%) | P < .032 | 8 (53%) | P > .1 |
| Range, 25%-80% | Range, 4-111 | |||||||||
| Pleomorphic (n = 14) | 53% (±39.9%) | 51.07 (±30.2) | 2 (14%) | 8/10 (80%) | 9 (64%) B.Common versus blastoid MCL types | |||||
| Range, 20%-90% | Range, 9-126 | |||||||||
| Common (n = 35) | 27% (±21.1%) | 21.26 (±15.4) | 2 (6%) | 2/26 (8%) | 14 (40%) | |||||
| Range, 5%-60% | Range, 2-71 | |||||||||
| Blastoid*(n = 29) | 55% (±48.3%) | P < .001 | 54.31 (±40.73) | P < .001 | 6 (21%) | P = .0713 | 13/24 (54%) | P = .0003 | 17 (59%) | P = .143 |
| Range, 20%-90% | Range, 4-126 | |||||||||
P is the results of the tests for equality.
Abbreviation: CI, 95% confidence interval.
Both lymphoblastoid and pleomorphic types.