Enhancement of Positive Selection in CD2, CD5 Double Knockout Mice
| Mutation . | No. Thymocytes × 10−7 (mean ± SEM) . | Percent of Total Thymocytes (mean ± SEM) . | |||
|---|---|---|---|---|---|
| . | . | CD4−8− . | CD4+8+ . | CD4+8− . | CD4−8+ . |
| WT | 13.7 ± 1.6 | 3 ± 0.6 | 84 ± 1.7 | 10 ± 1.2 | 3 ± 1.2 |
| CD2 | 14.7 ± 2.7 | 3 ± 1.2 | 81 ± 2.4 | 13 ± 0.6 | 3 ± 0.6 |
| CD5 | 17.8 ± 2.6 | 3 ± 0.6 | 82 ± 1.7 | 11 ± 1.7 | 4 ± 1.2 |
| CD2, CD5 | 12.8 ± 1.8 | 3 ± 0.6 | 72 ± 2.9 | 18 ± 1.7 | 7 ± 1.7 |
| Mutation . | No. Thymocytes × 10−7 (mean ± SEM) . | Percent of Total Thymocytes (mean ± SEM) . | |||
|---|---|---|---|---|---|
| . | . | CD4−8− . | CD4+8+ . | CD4+8− . | CD4−8+ . |
| WT | 13.7 ± 1.6 | 3 ± 0.6 | 84 ± 1.7 | 10 ± 1.2 | 3 ± 1.2 |
| CD2 | 14.7 ± 2.7 | 3 ± 1.2 | 81 ± 2.4 | 13 ± 0.6 | 3 ± 0.6 |
| CD5 | 17.8 ± 2.6 | 3 ± 0.6 | 82 ± 1.7 | 11 ± 1.7 | 4 ± 1.2 |
| CD2, CD5 | 12.8 ± 1.8 | 3 ± 0.6 | 72 ± 2.9 | 18 ± 1.7 | 7 ± 1.7 |
Three mice (5 to 10 weeks old) were analyzed per group. The same trends were also observed in a total of five different experiments that included the above combinations of mice.