Table 1. Effect of In Vivo Treatment... | American Society of Hematology

Table 1.

Effect of In Vivo Treatment With IFN-α on the Ability to Produce IL-4 and IFN-γ by CD8⁺ T-Cell Clones Generated From Skin Biopsies of HIV-Infected Patients With KS

Patient No.	No. of	Mean Values of Cytokine Production^*
(treatment)	Clones	IL-4 (ng/mL)	IFN-γ (ng/mL)
Patient no. 1
Before	146	1.66 ± 0.4^†	4.07 ± 0.2ρ
After	119	1.00 ± 0.1^†	8.89 ± 1.5ρ
Patient no. 2
Before	102	0.51 ± 0.1^‡	4.94 ± 0.4^1-155
After	64	0.17 ± 0.1^‡	7.42 ± 0.2^1-155

Patient No.	No. of	Mean Values of Cytokine Production^*
(treatment)	Clones	IL-4 (ng/mL)	IFN-γ (ng/mL)
Patient no. 1
Before	146	1.66 ± 0.4^†	4.07 ± 0.2ρ
After	119	1.00 ± 0.1^†	8.89 ± 1.5ρ
Patient no. 2
Before	102	0.51 ± 0.1^‡	4.94 ± 0.4^1-155
After	64	0.17 ± 0.1^‡	7.42 ± 0.2^1-155

Abbreviation: NS, not significant.

Clonal T cells were extensively washed, counted, and incubated at 10⁶/mL in the presence of PMA (20 ng/mL) plus anti-CD3 Ab (100 ng/mL) for 36 hours. The content of IL-4 and IFN-γ in T-cell clone supernatants was evaluated by ELISA kits, as described in Materials and Methods.

†

P, NS.

‡

P < .01.

ρ P < .005.

F1-155

P < .0001.

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