Table 4. Correlation Between the 2; 5... | American Society of Hematology

Table 4.

Correlation Between the 2; 5 Translocation and Immunocytochemical Labeling for NPM/ALK and ALK Protein Expression in ALCL

Case No.	Karyotype	Phenotype		RT-PCR^4-150	Immunostaining
		CD30^4-150	T/Null^4-150		ALK1	p80^4-150
1	t(2; 5)	+	T	+	+	+
2	t(2; 5)	+	NT	+	+	+
3	t(2; 5)	+	T	+	+	+
4	t(2; 5)	+	T	+	+	+
5	t(2; 5)	+	T	+	+	+
6	t(2; 5; 6)	+	T	+	+	+
7	t(2; 5)	+	T	NT	+	+
8	t(2; 5)	+	T	NT	+	+
9	t(2; 5)	+	NT	−	−	−
10	t(2; 5)	+	T	NT	+	NT
11	Normal	+	T	+	+	+
12	Normal	+	T	−	+	−
13	t(1; 2)	+	T	NT	+	+
14	NT	+	T	+	+	+
15	NT	+	T	+	+	+
16	NT	+	T	+	+	+
17	NT	+	Null	−	−	−
18	NT	+	T	−	−	(+)
19	NT	+	Null	−	+	(+)
20	NT	+	T	−	+	−
21	NT	+	NT	+	+	NT
22	NT	+	T	+	+	NT
23	NT	+	T	+	+	NT
24	NT	+	T	−	−	NT

Case No.	Karyotype	Phenotype		RT-PCR^4-150	Immunostaining
		CD30^4-150	T/Null^4-150		ALK1	p80^4-150
1	t(2; 5)	+	T	+	+	+
2	t(2; 5)	+	NT	+	+	+
3	t(2; 5)	+	T	+	+	+
4	t(2; 5)	+	T	+	+	+
5	t(2; 5)	+	T	+	+	+
6	t(2; 5; 6)	+	T	+	+	+
7	t(2; 5)	+	T	NT	+	+
8	t(2; 5)	+	T	NT	+	+
9	t(2; 5)	+	NT	−	−	−
10	t(2; 5)	+	T	NT	+	NT
11	Normal	+	T	+	+	+
12	Normal	+	T	−	+	−
13	t(1; 2)	+	T	NT	+	+
14	NT	+	T	+	+	+
15	NT	+	T	+	+	+
16	NT	+	T	+	+	+
17	NT	+	Null	−	−	−
18	NT	+	T	−	−	(+)
19	NT	+	Null	−	+	(+)
20	NT	+	T	−	+	−
21	NT	+	NT	+	+	NT
22	NT	+	T	+	+	NT
23	NT	+	T	+	+	NT
24	NT	+	T	−	−	NT

Abbreviations: (+), weak staining; NT, not tested.

Results obtained from present study and the study by Lamant et al.29