Immunocytochemical Reactivity of Lymphomas for ALK and NPM-ALK Proteins
| Histologic Type3-150 . | No. Positive/Tested . | Total . |
|---|---|---|
| ALCL | 42/77 | |
| CD30+ | 38/56 | |
| CD30+ Hodgkin's-like | 1/17 | |
| CD30− (EMA+) | 3/4 | |
| Hodgkin's disease3-151 | 0/50 | |
| Lymphomatoid papulosis | 0/8 | |
| T-cell lymphomas | 0/22 | |
| Precursor T-lymphoblastic lymphomas | 0/3 | |
| T-cell chronic lymphocytic leukemia | 0/1 | |
| Mycosis fungoides/Sezary syndrome | 0/2 | |
| Peripheral T-cell lymphoma, unspecified | 0/16 | |
| B-cell lymphomas | 0/82 | |
| Precursor B-lymphoblastic lymphomas | 0/1 | |
| B-cell chronic lymphocytic leukemia | 0/10 | |
| Immunocytoma/lymphoplasmacytic lymphoma | 0/3 | |
| Mantle cell lymphoma | 0/4 | |
| Follicular center lymphoma | 0/12 | |
| Nodal monocytoid B-cell lymphoma | 0/1 | |
| Hairy cell leukemia | 0/4 | |
| Plasmacytoma/myeloma | 0/2 | |
| Diffuse large B-cell lymphoma | 0/36 | |
| Unclassified high grade | 0/6 | |
| Unclassified low grade | 0/3 | |
| Total no. of cases tested | 42/239 |
| Histologic Type3-150 . | No. Positive/Tested . | Total . |
|---|---|---|
| ALCL | 42/77 | |
| CD30+ | 38/56 | |
| CD30+ Hodgkin's-like | 1/17 | |
| CD30− (EMA+) | 3/4 | |
| Hodgkin's disease3-151 | 0/50 | |
| Lymphomatoid papulosis | 0/8 | |
| T-cell lymphomas | 0/22 | |
| Precursor T-lymphoblastic lymphomas | 0/3 | |
| T-cell chronic lymphocytic leukemia | 0/1 | |
| Mycosis fungoides/Sezary syndrome | 0/2 | |
| Peripheral T-cell lymphoma, unspecified | 0/16 | |
| B-cell lymphomas | 0/82 | |
| Precursor B-lymphoblastic lymphomas | 0/1 | |
| B-cell chronic lymphocytic leukemia | 0/10 | |
| Immunocytoma/lymphoplasmacytic lymphoma | 0/3 | |
| Mantle cell lymphoma | 0/4 | |
| Follicular center lymphoma | 0/12 | |
| Nodal monocytoid B-cell lymphoma | 0/1 | |
| Hairy cell leukemia | 0/4 | |
| Plasmacytoma/myeloma | 0/2 | |
| Diffuse large B-cell lymphoma | 0/36 | |
| Unclassified high grade | 0/6 | |
| Unclassified low grade | 0/3 | |
| Total no. of cases tested | 42/239 |
All cases were tested as paraffin sections with MoAb, AKL1 as described in the text.
Neoplasms were categorized according to the REAL30 classification of lymphoid malignancy.
Subtypes of Hodgkin's disease studied comprised 4 cases of lymphocyte predominance, 22 cases of nodular sclerosis, and 24 cases of mixed cellularity.