Table 2. Ig V H , D, J H , and C H Genes... | American Society of Hematology

Table 2.

Ig V_H , D, J_H , and C_H Genes of Leukemic B Cells in Five IgA and/or IgG CLLs

Patient	C_H Gene	V_H Gene
		Closest Germline Gene	Nucleotide Identity %	CDR1 and CDR			FR1, FR2, and FR3			D Gene	J_H Gene	Intraclonal Divergence
				R	p	S	R	p	S
TR	α	V_H251 (V5-51)	100.0	0 (0.00)	—	0	0 (0.00)	—	0	LR3	J_H4	No
KA	α	DP-14 (V1-18)	97.9	4 (1.17)	1.65 × 10⁻² ^*	1	1 (4.07)	2.17 × 10⁻² ^*	0	ND	J_H4	No
GR	α	DP-42 (V3-53)	97.6	0 (0.00)	—	0	2 (5.29)	2.50 × 10⁻² ^*	5	XP4	J_H4	No
TE	α/γ	V_H26 (V3-23)	88.8	13 (7.70)	1.93 × 10⁻² ^*	1	11 (25.33)	9.00 × 10⁻⁶ ^*	8	ND	J_H4	No
SC	γ	V_H4.21 (V4-34)	95.9	1 (3.36)	0.10	0	7 (10.89)	3.71 × 10⁻²	4	ND	J_H6	No

Patient	C_H Gene	V_H Gene
		Closest Germline Gene	Nucleotide Identity %	CDR1 and CDR			FR1, FR2, and FR3			D Gene	J_H Gene	Intraclonal Divergence
				R	p	S	R	p	S
TR	α	V_H251 (V5-51)	100.0	0 (0.00)	—	0	0 (0.00)	—	0	LR3	J_H4	No
KA	α	DP-14 (V1-18)	97.9	4 (1.17)	1.65 × 10⁻² ^*	1	1 (4.07)	2.17 × 10⁻² ^*	0	ND	J_H4	No
GR	α	DP-42 (V3-53)	97.6	0 (0.00)	—	0	2 (5.29)	2.50 × 10⁻² ^*	5	XP4	J_H4	No
TE	α/γ	V_H26 (V3-23)	88.8	13 (7.70)	1.93 × 10⁻² ^*	1	11 (25.33)	9.00 × 10⁻⁶ ^*	8	ND	J_H4	No
SC	γ	V_H4.21 (V4-34)	95.9	1 (3.36)	0.10	0	7 (10.89)	3.71 × 10⁻²	4	ND	J_H6	No

Abbreviations: R, number of detected and (expected) R mutations; S, number of detected S mutations; p, probability; ND, not determined.

Statistically significant.