Results of Autologous Transplantation for CML With or Without Ex Vivo Purging of Autografts
| Study . | Purging Method . | Stem Cell Source . | Patients Transplanted . | Cytogenetic Response . | Median Survival (range) . | |
|---|---|---|---|---|---|---|
| . | . | . | . | CR . | PR (%PH−) . | in Months . |
| Without purging | ||||||
| Blast crisis | ||||||
| Haines37 (Hammersmith) | None | PB | 51 | 0 | 3 (14-67) | 26 (0.5-35) |
| Reiffers38 (Bordeaux) | None | PB | 47 | 0 | 14 (>10) | 24 (4-49) |
| Chronic phase | ||||||
| Hoyle39 (Hammersmith) | None | PB | 21 | 2 | 9 (not defined) | 82 (9-105) |
| Reiffers40 (EBMTR) | None | PB + BM | 49 | 10 | 5 (>65) | — |
| 81% survival at 3 yr | ||||||
| With ex vivo purging | ||||||
| Carlo-Stella42 (Parma) | Mafosfamide | BM | 10* | 6 | 1 (75%) | — |
| McGlave43 (Minnesota) | IFN-γ | BM | 44 | 10 | 12 (15-95%) | — |
| CP 71% survival at 3 yr | ||||||
| AP 15% survival at 3 yr | ||||||
| Barnett44 (Vancouver) | Marrow culture | BM | 22† | 13 | 3 (>75%) | — |
| CP 81% survival at 5 yr | ||||||
| AP 50% survival at 4 yr | ||||||
| Study . | Purging Method . | Stem Cell Source . | Patients Transplanted . | Cytogenetic Response . | Median Survival (range) . | |
|---|---|---|---|---|---|---|
| . | . | . | . | CR . | PR (%PH−) . | in Months . |
| Without purging | ||||||
| Blast crisis | ||||||
| Haines37 (Hammersmith) | None | PB | 51 | 0 | 3 (14-67) | 26 (0.5-35) |
| Reiffers38 (Bordeaux) | None | PB | 47 | 0 | 14 (>10) | 24 (4-49) |
| Chronic phase | ||||||
| Hoyle39 (Hammersmith) | None | PB | 21 | 2 | 9 (not defined) | 82 (9-105) |
| Reiffers40 (EBMTR) | None | PB + BM | 49 | 10 | 5 (>65) | — |
| 81% survival at 3 yr | ||||||
| With ex vivo purging | ||||||
| Carlo-Stella42 (Parma) | Mafosfamide | BM | 10* | 6 | 1 (75%) | — |
| McGlave43 (Minnesota) | IFN-γ | BM | 44 | 10 | 12 (15-95%) | — |
| CP 71% survival at 3 yr | ||||||
| AP 15% survival at 3 yr | ||||||
| Barnett44 (Vancouver) | Marrow culture | BM | 22† | 13 | 3 (>75%) | — |
| CP 81% survival at 5 yr | ||||||
| AP 50% survival at 4 yr | ||||||