Table 1. Platelet Coagulant Values . . .... | American Society of Hematology

Table 1.

Platelet Coagulant Values

			Platelet Factor V	Prothrombinase^*
					Collagen + Thrombin	Collagen + Thrombin (−Va)
Platelet Defect	Subject Disorder	PF3a (s)	(U/10¹¹)	Thrombin	(pmol thrombin/10⁸ plts)

None	Controls
	x̄	43	68	1,057	1,899	1,366
	SD	4	19	370	491	304
	SE	1	5	85	113	72
	(n)	(30)	(15)	(19)	(19)	(19)
PCA (PF3a)	Scott	74†	51	543	631†	437†
	MP	57†	42	593	1,265	720†
	MSn	60†	62	759	1,507	1,024¶
Dense granules	δ-SPD	48 ± 1^‡	63 ± 4	627 ± 96^‡	1,209 ± 103ρ	804 ± 105ρ
	HPS (n = 10)
	Non-HPS
ES	65†	60	574	678†	526†
	NS	55†	60	522	668†	417†
	Other (n = 5)	42 ± 2	77 ± 7	671 ± 113	1,605 ± 163	1,041 ± 111^∥
α- and dense granules	αδ-SPD	76†	33	440	585†	620†
α-Granules	α-SPD	45	7†	368	908†	329†
α-Granule V	Factor V	65†	8†	1,266	1,824	462†
GPIIbIIIa	TSA (n = 5)	58 ± 4ρ	122 ± 18^‡	1,031 ± 181	1,617 ± 227	1,299 ± 123

			Platelet Factor V	Prothrombinase^*
					Collagen + Thrombin	Collagen + Thrombin (−Va)
Platelet Defect	Subject Disorder	PF3a (s)	(U/10¹¹)	Thrombin	(pmol thrombin/10⁸ plts)

None	Controls
	x̄	43	68	1,057	1,899	1,366
	SD	4	19	370	491	304
	SE	1	5	85	113	72
	(n)	(30)	(15)	(19)	(19)	(19)
PCA (PF3a)	Scott	74†	51	543	631†	437†
	MP	57†	42	593	1,265	720†
	MSn	60†	62	759	1,507	1,024¶
Dense granules	δ-SPD	48 ± 1^‡	63 ± 4	627 ± 96^‡	1,209 ± 103ρ	804 ± 105ρ
	HPS (n = 10)
	Non-HPS
ES	65†	60	574	678†	526†
	NS	55†	60	522	668†	417†
	Other (n = 5)	42 ± 2	77 ± 7	671 ± 113	1,605 ± 163	1,041 ± 111^∥
α- and dense granules	αδ-SPD	76†	33	440	585†	620†
α-Granules	α-SPD	45	7†	368	908†	329†
α-Granule V	Factor V	65†	8†	1,266	1,824	462†
GPIIbIIIa	TSA (n = 5)	58 ± 4ρ	122 ± 18^‡	1,031 ± 181	1,617 ± 227	1,299 ± 123

Values are picomoles thrombin formed per 10⁸ platelets during a 1-minute incubation period in the prothrombinase assay (see Materials and Methods). Platelet activation was for 10 minutes with stirring.

†

>2 SD v controls.

P values v controls: ∥ <.05, ‡ <.01, ρ <.001.

F1-154

Average of four values (1,395, 733, 732, 1,236).

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