Summary of the Clinical Data, Serum Antibodies, and PCR Studies
| . | Age/Sex . | Diagnosis . | Serum Antibodies . | Detection of HTLV-1 DNA . | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | PA . | ELISA . | Skin . | PBMC . | T-Cell Clones . | . | . | . | . | . | . | . | . | . | |||||||||
| . | . | . | . | . | gag . | pol . | env . | px . | gag . | pol . | env . | pX . | gag . | pol . | env . | pX . | . | . | . | . | . | . | . | . | . |
| 1 | 57 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 2 | 45 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 3 | 33 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 4 | 54 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 5 | 55 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 6 | 28 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 7 | 46 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 8 | 68 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 9 | 24 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 10 | 72 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 11 | 69 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 12 | 45 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 13 | 58 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 14 | 53 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 15 | 81 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 16 | 88 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 17 | 75 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 18 | 50 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 19 | 29 m | MF t | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 20 | 26 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 21 | 41 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 22 | 50 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 23 | 77 f | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 24 | 53 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 25 | 46 m | MF t | — | <0.395 | — | — | — | — | nd | — | — | — | — | ||||||||||||
| 26 | 77 f | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 27 | 57 m | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 28 | 87 f | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 29 | 45 m | SS | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 30 | 42 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 31 | 70 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 32 | 43 m | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 33 | 54 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 34 | 55 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 35 | 63 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 36 | 65 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 37 | 77 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 38 | 65 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 39 | 34 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 40 | 54 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 41 | 85 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 42 | 80 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 43 | 45 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 44 | 49 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 45 | 53 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 46 | 88 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 47 | 35 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 48 | 48 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 49 | 29 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 50 | 70 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 51 | 65 m | sATLL | + | 2.20< | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | |||||||||
| 52 | 54 m | CTCL+ | + | 2.16 | + | + | + | + | + | + | + | + | + | + | + | + | |||||||||
| 53 | 59 f | CTCL+ | + | 0.94 | + | + | + | + | + | + | + | + | + | + | + | + | |||||||||
| . | Age/Sex . | Diagnosis . | Serum Antibodies . | Detection of HTLV-1 DNA . | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | PA . | ELISA . | Skin . | PBMC . | T-Cell Clones . | . | . | . | . | . | . | . | . | . | |||||||||
| . | . | . | . | . | gag . | pol . | env . | px . | gag . | pol . | env . | pX . | gag . | pol . | env . | pX . | . | . | . | . | . | . | . | . | . |
| 1 | 57 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 2 | 45 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 3 | 33 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 4 | 54 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 5 | 55 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 6 | 28 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 7 | 46 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 8 | 68 m | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 9 | 24 f | MF e | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 10 | 72 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 11 | 69 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 12 | 45 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 13 | 58 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 14 | 53 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 15 | 81 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 16 | 88 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 17 | 75 f | MF p | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 18 | 50 m | MF p | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 19 | 29 m | MF t | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 20 | 26 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 21 | 41 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 22 | 50 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 23 | 77 f | MF t | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 24 | 53 m | MF t | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 25 | 46 m | MF t | — | <0.395 | — | — | — | — | nd | — | — | — | — | ||||||||||||
| 26 | 77 f | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 27 | 57 m | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 28 | 87 f | SS | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 29 | 45 m | SS | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 30 | 42 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 31 | 70 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 32 | 43 m | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 33 | 54 f | Ki-1+CTCL | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 34 | 55 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 35 | 63 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 36 | 65 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 37 | 77 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | ne | ||||||||||||
| 38 | 65 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 39 | 34 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 40 | 54 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 41 | 85 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 42 | 80 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 43 | 45 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 44 | 49 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 45 | 53 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 46 | 88 m | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 47 | 35 m | CTCL* | — | <0.395 | — | — | — | — | nd | nd | |||||||||||||||
| 48 | 48 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 49 | 29 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 50 | 70 f | CTCL* | — | <0.395 | — | — | — | — | — | — | — | — | — | — | — | — | |||||||||
| 51 | 65 m | sATLL | + | 2.20< | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | |||||||||
| 52 | 54 m | CTCL+ | + | 2.16 | + | + | + | + | + | + | + | + | + | + | + | + | |||||||||
| 53 | 59 f | CTCL+ | + | 0.94 | + | + | + | + | + | + | + | + | + | + | + | + | |||||||||
Abbreviations: PA, particle agglutination; ELISA, enzyme-linked immunosorbent assay (cut off < 0.395); PBMC, peripheral blood mononuclear cells; nd, not done; ne, not established; MF, mycosis fungoides (e, erythema stage; p, plaque stage; t, tumor stage); SS, Sezary syndrome; Ki-1+CTCL, primary cutaneous anaplastic large cell lymphoma of T-cell type expressing Ki-1 (CD30) antigen; CTCL*, cutaneous T-cell lymphoma other than MF, SS, or Ki-1+CTCL; CTCL+, CTCL in HTLV-1 carrier; sATLL smouldering adult T-cell leukemia/lymphoma.