hMLH1 Alterations in Human Leukemia and Lymphoma Cell Lines
| . | Mutation of the Gene . | mRNA . | Protein . | |||
|---|---|---|---|---|---|---|
| . | Exon 2 . | Exon 9 . | Exon 15 . | Exon 16 . | . | . |
| Myeloid/monocytic | ||||||
| HL60 | W | W | W | W | + | + |
| SKH1 | W | W | W | W | ND | ND |
| KG1 | W | W | W | W | ND | ND |
| KU812 | W | W | W | W | ND | ND |
| ME-F2 | W | W | W | W | ND | ND |
| JOSK-K | W | W | W | W | ND | ND |
| JOSK-S | W | W | W | W | ND | ND |
| P39 TSU | W | W | W | W | ND | ND |
| THP1 | W | W | W | W | + | ND |
| U937 | W | W | W | W | ND | ND |
| ML1 | W | W | W | W | + | ND |
| Erythroid | ||||||
| F36E | W | W | W | W | ND | ND |
| K562 | W | W | W | W | ND | ND |
| HEL | W | W | W | W | + | ND |
| TF1 | W | W | W | W | + | ND |
| Megakaryocytic | ||||||
| UT7 | W | W | W | W | ND | ND |
| CMK | W | W | W | W | ND | ND |
| MegJ | W | W | W | W | + | ND |
| MOLM1 | W | W | W | W | ND | ND |
| SUM90-7 | W | W | W | W | ND | ND |
| B-lymphocytic | ||||||
| BALL-1 | W | W | W | W | + | ND |
| Daudi | W | W | W | W | + | + |
| Raji | W | W | W | W | + | + |
| IM9 | W | W | W | W | ND | ND |
| M5 | W | W | W | W | ND | ND |
| HA | W | W | W | W | + | + |
| P32 ISH | W | W | W | W | ND | ND |
| SCMCL-L1 | W | W | W | W | ND | ND |
| SCMCL-L3 | W | W | W | W | ND | ND |
| SCMCL-L4 | W | W | W | W | ND | ND |
| KPMM1 | W | W | W | W | ND | ND |
| KCL22 | W | M | W | W | − | − |
| Ramos | ND | ND | ND | ND | + | ND |
| BALM1 | ND | ND | ND | ND | + | ND |
| Ri-1 | ND | ND | ND | ND | + | ND |
| RPMI8226 | ND | ND | ND | ND | + | ND |
| DND39 | ND | ND | ND | ND | + | ND |
| T-lymphocytic | ||||||
| Jurkat | W | W | W | W | + | ND |
| A3/KAW | W | W | W | W | ND | + |
| MOLT4 | W | W | W | W | + | + |
| MOLT16 | W | W | W | W | + | + |
| P30OHK | W | M | W | W | − | − |
| SKW3 | W | W | W | W | + | ND |
| CEM | W | M | W | W | + | − |
| MT1 | W | W | W | W | ND | ND |
| HUT78 | W | W | W | W | ND | ND |
| Peer | W | W | W | W | ND | ND |
| TALL1 | W | W | W | W | ND | ND |
| . | Mutation of the Gene . | mRNA . | Protein . | |||
|---|---|---|---|---|---|---|
| . | Exon 2 . | Exon 9 . | Exon 15 . | Exon 16 . | . | . |
| Myeloid/monocytic | ||||||
| HL60 | W | W | W | W | + | + |
| SKH1 | W | W | W | W | ND | ND |
| KG1 | W | W | W | W | ND | ND |
| KU812 | W | W | W | W | ND | ND |
| ME-F2 | W | W | W | W | ND | ND |
| JOSK-K | W | W | W | W | ND | ND |
| JOSK-S | W | W | W | W | ND | ND |
| P39 TSU | W | W | W | W | ND | ND |
| THP1 | W | W | W | W | + | ND |
| U937 | W | W | W | W | ND | ND |
| ML1 | W | W | W | W | + | ND |
| Erythroid | ||||||
| F36E | W | W | W | W | ND | ND |
| K562 | W | W | W | W | ND | ND |
| HEL | W | W | W | W | + | ND |
| TF1 | W | W | W | W | + | ND |
| Megakaryocytic | ||||||
| UT7 | W | W | W | W | ND | ND |
| CMK | W | W | W | W | ND | ND |
| MegJ | W | W | W | W | + | ND |
| MOLM1 | W | W | W | W | ND | ND |
| SUM90-7 | W | W | W | W | ND | ND |
| B-lymphocytic | ||||||
| BALL-1 | W | W | W | W | + | ND |
| Daudi | W | W | W | W | + | + |
| Raji | W | W | W | W | + | + |
| IM9 | W | W | W | W | ND | ND |
| M5 | W | W | W | W | ND | ND |
| HA | W | W | W | W | + | + |
| P32 ISH | W | W | W | W | ND | ND |
| SCMCL-L1 | W | W | W | W | ND | ND |
| SCMCL-L3 | W | W | W | W | ND | ND |
| SCMCL-L4 | W | W | W | W | ND | ND |
| KPMM1 | W | W | W | W | ND | ND |
| KCL22 | W | M | W | W | − | − |
| Ramos | ND | ND | ND | ND | + | ND |
| BALM1 | ND | ND | ND | ND | + | ND |
| Ri-1 | ND | ND | ND | ND | + | ND |
| RPMI8226 | ND | ND | ND | ND | + | ND |
| DND39 | ND | ND | ND | ND | + | ND |
| T-lymphocytic | ||||||
| Jurkat | W | W | W | W | + | ND |
| A3/KAW | W | W | W | W | ND | + |
| MOLT4 | W | W | W | W | + | + |
| MOLT16 | W | W | W | W | + | + |
| P30OHK | W | M | W | W | − | − |
| SKW3 | W | W | W | W | + | ND |
| CEM | W | M | W | W | + | − |
| MT1 | W | W | W | W | ND | ND |
| HUT78 | W | W | W | W | ND | ND |
| Peer | W | W | W | W | ND | ND |
| TALL1 | W | W | W | W | ND | ND |
Abbreviations: W, wild type; M, mutation; ND, not done; +, normal expression; −, loss.