Baseline and ACS Laboratory Values According to Age
| . | Total . | Age (yr) . | ||||
|---|---|---|---|---|---|---|
| . | . | <2 . | 2-4 . | 5-9 . | 10-19 . | 20+ . |
| Hemoglobin SS patients | ||||||
| Baseline Hb (g/dL) | 8.5 ± 1.3 | 8.7 ± 1.1 | 8.5 ± 1.11 | 8.1 ± 1.0 | 8.2 ± 1.0 | 9.0 ± 1.5 |
| ACS Hb (g/dL) | 7.9 ± 1.5 | 8.3 ± 1.5 | 7.8 ± 1.5 | 7.4 ± 1.3 | 7.7 ± 1.3 | 8.2 ± 1.6 |
| Baseline WBC (1,000/μL) | 13.3 ± 3.9 | 17 ± 7.0 | 14.6 ± 4.5 | 13.2 ± 3.3 | 12.4 ± 3.0 | 12.3 ± 2.8 |
| ACS WBC (1,000/μL) | 21.1 ± 8.6 | 21.5 ± 10.0 | 21.5 ± 8.9 | 22.3 ± 9.1 | 21.5 ± 7.6 | 19.4 ± 7.7 |
| PMN (% of differential) | 62 ± 16 | 46 ± 20 | 58 ± 15 | 64 ± 14 | 67 ± 14 | 65 ± 12 |
| Any NRBC (% of patients) | 47 | 36 | 42 | 47 | 47 | 55 |
| No. of patients | 738 | 92 | 136 | 151 | 154 | 205 |
| Hemoglobin SC patients | ||||||
| Baseline Hb (g/dL) | 11.2 ± 1.3 | 10.3 ± 0.4 | 10.6 ± 0.8 | 10.8 ± 0.8 | 11.5 ± 1.2 | 12.2 ± 1.6 |
| ACS Hb (g/dL) | 10.3 ± 1.6 | 9.9 ± 1.2 | 9.7 ± 1.3 | 9.9 ± 1.5 | 10.6 ± 1.8 | 11.2 ± 1.8 |
| Baseline WBC (1,000/μL) | 9.1 ± 2.7 | 10.7 ± 2.7 | 10.1 ± 3.3 | 8.1 ± 1.5 | 7.6 ± 1.9 | 9.6 ± 2.8 |
| ACS WBC (1,000/μL) | 15.8 ± 7.5 | 18.6 ± 8.8 | 16.4 ± 8.2 | 14.6 ± 5.0 | 13.6 ± 6.0 | 16.0 ± 8.3 |
| PMN (% of differential) | 62 ± 15 | 50 ± 18 | 59 ± 15 | 70 ± 13 | 64 ± 11 | 68 ± 11 |
| Any NRBC (% of patients) | 15 | 4 | 7 | 10 | 22 | 30 |
| No. of patients | 127 | 26 | 27 | 20 | 27 | 27 |
| . | Total . | Age (yr) . | ||||
|---|---|---|---|---|---|---|
| . | . | <2 . | 2-4 . | 5-9 . | 10-19 . | 20+ . |
| Hemoglobin SS patients | ||||||
| Baseline Hb (g/dL) | 8.5 ± 1.3 | 8.7 ± 1.1 | 8.5 ± 1.11 | 8.1 ± 1.0 | 8.2 ± 1.0 | 9.0 ± 1.5 |
| ACS Hb (g/dL) | 7.9 ± 1.5 | 8.3 ± 1.5 | 7.8 ± 1.5 | 7.4 ± 1.3 | 7.7 ± 1.3 | 8.2 ± 1.6 |
| Baseline WBC (1,000/μL) | 13.3 ± 3.9 | 17 ± 7.0 | 14.6 ± 4.5 | 13.2 ± 3.3 | 12.4 ± 3.0 | 12.3 ± 2.8 |
| ACS WBC (1,000/μL) | 21.1 ± 8.6 | 21.5 ± 10.0 | 21.5 ± 8.9 | 22.3 ± 9.1 | 21.5 ± 7.6 | 19.4 ± 7.7 |
| PMN (% of differential) | 62 ± 16 | 46 ± 20 | 58 ± 15 | 64 ± 14 | 67 ± 14 | 65 ± 12 |
| Any NRBC (% of patients) | 47 | 36 | 42 | 47 | 47 | 55 |
| No. of patients | 738 | 92 | 136 | 151 | 154 | 205 |
| Hemoglobin SC patients | ||||||
| Baseline Hb (g/dL) | 11.2 ± 1.3 | 10.3 ± 0.4 | 10.6 ± 0.8 | 10.8 ± 0.8 | 11.5 ± 1.2 | 12.2 ± 1.6 |
| ACS Hb (g/dL) | 10.3 ± 1.6 | 9.9 ± 1.2 | 9.7 ± 1.3 | 9.9 ± 1.5 | 10.6 ± 1.8 | 11.2 ± 1.8 |
| Baseline WBC (1,000/μL) | 9.1 ± 2.7 | 10.7 ± 2.7 | 10.1 ± 3.3 | 8.1 ± 1.5 | 7.6 ± 1.9 | 9.6 ± 2.8 |
| ACS WBC (1,000/μL) | 15.8 ± 7.5 | 18.6 ± 8.8 | 16.4 ± 8.2 | 14.6 ± 5.0 | 13.6 ± 6.0 | 16.0 ± 8.3 |
| PMN (% of differential) | 62 ± 15 | 50 ± 18 | 59 ± 15 | 70 ± 13 | 64 ± 11 | 68 ± 11 |
| Any NRBC (% of patients) | 15 | 4 | 7 | 10 | 22 | 30 |
| No. of patients | 127 | 26 | 27 | 20 | 27 | 27 |
Difference between acute and baseline Hb levels and WBC count was significant (P < .05) for each age group for both Hb SS and Hb SC patients. The degree of Hb drop was consistent in the Hb SS and Hb SC genotypes. Results reflect symptoms from only first episode of ACS for each patient.
Abbreviations: ACS, acute chest syndrome; Hb, hemoglobin; WBC, white blood cell; PMN, polymorphonuclear cells; NRBC, nucleated red blood cell.