Table 1. Marrow Grafts From... | American Society of Hematology

Table 1.

Marrow Grafts From DLA-Identical Littermates After Conditioning With Sublethal TBI Delivered at 7 cGy/min or No Conditioning

Group	TBI Dose (cGy)	Postgrafting Immunosuppression	Recipient No.	Sustained Allograft	GVHD		Rejection	Complete Autologous Recovery	Duration of Mixed Hematopoietic Chimerism by (CA)_n Dinucleotide Repeat Marker Studies
					Acute	Chronic			(weeks after marrow graft)
1	200	CSP^*	D902	No	—	—	Yes	Yes	4
			D944	No	—	—	Yes	Yes	4
			E026	No	—	—	Yes	Yes	4
			E027	No	—	—	Yes	Yes	4
2	200	MTX†/CSP^*	E126	No	—	—	Yes	Yes	7
			E127	No	—	—	Yes	Yes	2
			E156	No	—	—	Yes	Yes	11
			E157	Yes	No	No	No	No	>8ρ
			E200	Yes	No	No	No	No	>60
			E203	Yes	No	No	No	No	>60
3	200	MMF‡/CSP^*	E131	Yes	No	No	No	No	>57^1-155
			E219	Yes	No	No	No	No	>54
			E220	Yes	No	No	No	No	>54
			E066	Yes	No	No	No	No	>56
			E069	No	No	No	Yes	Yes	12
4	100	MMF‡/CSP^*	E165	No	—	—	Yes	Yes	12
			E166	No	—	—	Yes	Yes	10
			E202	No	—	—	Yes	Yes	3
			E204	No	—	—	Yes	Yes	3
			E227	No	—	—	Yes	Yes	10
			E228	No	—	—	Yes	Yes	10
5	None	MMF‡/CSP^*	E242	No	—	—	Yes	Yes	2
			E244	No	—	—	Yes	Yes	2

Group	TBI Dose (cGy)	Postgrafting Immunosuppression	Recipient No.	Sustained Allograft	GVHD		Rejection	Complete Autologous Recovery	Duration of Mixed Hematopoietic Chimerism by (CA)_n Dinucleotide Repeat Marker Studies
					Acute	Chronic			(weeks after marrow graft)
1	200	CSP^*	D902	No	—	—	Yes	Yes	4
			D944	No	—	—	Yes	Yes	4
			E026	No	—	—	Yes	Yes	4
			E027	No	—	—	Yes	Yes	4
2	200	MTX†/CSP^*	E126	No	—	—	Yes	Yes	7
			E127	No	—	—	Yes	Yes	2
			E156	No	—	—	Yes	Yes	11
			E157	Yes	No	No	No	No	>8ρ
			E200	Yes	No	No	No	No	>60
			E203	Yes	No	No	No	No	>60
3	200	MMF‡/CSP^*	E131	Yes	No	No	No	No	>57^1-155
			E219	Yes	No	No	No	No	>54
			E220	Yes	No	No	No	No	>54
			E066	Yes	No	No	No	No	>56
			E069	No	No	No	Yes	Yes	12
4	100	MMF‡/CSP^*	E165	No	—	—	Yes	Yes	12
			E166	No	—	—	Yes	Yes	10
			E202	No	—	—	Yes	Yes	3
			E204	No	—	—	Yes	Yes	3
			E227	No	—	—	Yes	Yes	10
			E228	No	—	—	Yes	Yes	10
5	None	MMF‡/CSP^*	E242	No	—	—	Yes	Yes	2
			E244	No	—	—	Yes	Yes	2

CSP, 15 mg/kg bid orally on days −1 to 35.

MTX, 0.4 mg/kg IV on days 1, 3, 6, and 11.

MMF, 10 mg/kg bid SC on days 0-27.

ρ Dog was euthanized because of massive papillomata on feet related to CSP-induced immunosuppression.

Dog was euthanized at the completion of the study.