Number and Size of IMPs in the Homozygous Protein 4.1 (−) Madrid
| IMPs . | Normal . | Protein 4.1 (−) Madrid . |
|---|---|---|
| . | (n = 20) . | (n = 1) . |
| No. (/μm2) | 5,390 ± 420 | 5,275 ± 329 |
| Size (%) | ||
| Small (4-8 nm) | 71 ± 8 | 68 ± 9 |
| Medium (9-20 nm) | 27 ± 3 | 29 ± 5 |
| Large (>21 nm) | 2 ± 1 | 3 ± 2 |
| IMPs . | Normal . | Protein 4.1 (−) Madrid . |
|---|---|---|
| . | (n = 20) . | (n = 1) . |
| No. (/μm2) | 5,390 ± 420 | 5,275 ± 329 |
| Size (%) | ||
| Small (4-8 nm) | 71 ± 8 | 68 ± 9 |
| Medium (9-20 nm) | 27 ± 3 | 29 ± 5 |
| Large (>21 nm) | 2 ± 1 | 3 ± 2 |
Intact RBCs were subjected to EM studies using the FF method. The number of IMPs at the inner (so-called “P”) face in the homozygous protein 4.1 (−) Madrid (n = 1, obs 28) as compared with that in the normal subjects (n = 20, obs 121) was counted. The results are shown as the number of IMPs per square micrometer. The size of IMPs was also evaluated, and the results are shown in percentages. Mean values and 1 SD are shown.