Table 4. Mean LD70 and LCS for Each Drug... | American Society of Hematology

Table 4.

Mean LD70 and LCS for Each Drug for Each of the Three Prognostic Groups

Drugs and Factors	Mean LD70 (μg/mL)			Post Hoc
	or Mean Value			Test (P Value)
	CCR	IF/e.rel	Late rel
DNR	0.119^4-150	0.314^4-150	0.19	.001
ACR	0.168	0.211	0.164	.827
VP16	3.12	5.77	2.94	.19
L-ASP	3.42^4-150	5.88^4-150	4.28	.046
THP-ADR	0.225^4-150	0.395^4-150	0.241	.044
MIT	0.127^4-150	0.249^*†	0.121^4-151	.009*, .018^4-151
L-PAM	15.4	25.7	13.6	.337
4HC	7.85^4-150	15.57^4-150	9.54	.012
AraC	6.73^4-150	15.05^4-150	8.33	.025
MTX	449.8	482.9	455.9	.641
BLM	26.9^4-150	40.0^4-150	31.7	.012
VCR	0.590^4-150	0.836^4-150	0.742	.039
VLB	4.15^4-150	6.6^4-150	4.67	.033
MMC	0.34^4-150	0.66^4-150	0.46	.025
Pred (%)	33.1^4-150	50.4^4-150	37.2	.011
Dex (%)	36.6	46.8	41.6	.319
Age (yr)	6.9	8.2	6.8	.501
Bone marrow blasts (%)	89.3	90.4	87.5	.681
Absorbance (1 × 10⁵/w)	0.136^4-150	0.22^4-150	0.156	.005
Initial WBC (median, ×10³/μL)	28.1^*‡	95.3^*†	53.3^†‡	.0001*, .024^4-151
				.037^‡

Drugs and Factors	Mean LD70 (μg/mL)			Post Hoc
	or Mean Value			Test (P Value)
	CCR	IF/e.rel	Late rel
DNR	0.119^4-150	0.314^4-150	0.19	.001
ACR	0.168	0.211	0.164	.827
VP16	3.12	5.77	2.94	.19
L-ASP	3.42^4-150	5.88^4-150	4.28	.046
THP-ADR	0.225^4-150	0.395^4-150	0.241	.044
MIT	0.127^4-150	0.249^*†	0.121^4-151	.009*, .018^4-151
L-PAM	15.4	25.7	13.6	.337
4HC	7.85^4-150	15.57^4-150	9.54	.012
AraC	6.73^4-150	15.05^4-150	8.33	.025
MTX	449.8	482.9	455.9	.641
BLM	26.9^4-150	40.0^4-150	31.7	.012
VCR	0.590^4-150	0.836^4-150	0.742	.039
VLB	4.15^4-150	6.6^4-150	4.67	.033
MMC	0.34^4-150	0.66^4-150	0.46	.025
Pred (%)	33.1^4-150	50.4^4-150	37.2	.011
Dex (%)	36.6	46.8	41.6	.319
Age (yr)	6.9	8.2	6.8	.501
Bone marrow blasts (%)	89.3	90.4	87.5	.681
Absorbance (1 × 10⁵/w)	0.136^4-150	0.22^4-150	0.156	.005
Initial WBC (median, ×10³/μL)	28.1^*‡	95.3^*†	53.3^†‡	.0001*, .024^4-151
				.037^‡

Abbreviations: CCR, continuous complete remission; IF/e.rel, induction failure or relapse within 180 days of diagnosis; Late rel, relapse 181 or more days after diagnosis.

F4-150

Statistically significant for two categories: CCR v IF/e.rel.

F4-151

Statistically significant for two categories: IF/e.rel v late rel.

‡

Statistically significant for two categories: CCR v late rel.

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