Table 2. Defective Cell Death Induction... | American Society of Hematology

Table 2.

Defective Cell Death Induction by Fas Triggering in T Cells From Patients With ALD and Not in Patients With Typical Chronic ITP

Treatment	Incubation	Specific Cell Survival %^*			Statistical Analysis^†
	Time (hr)	I	II	III	II v III	I v III	I v II
		Normal Controls^‡	Patients with Chronic ITP	Patients with ALD	P <	P <	P <
		(n = 16)	(n = 12)	(n = 7)
Anti-Fas	18	59 ± 9	56 ± 6	89 ± 17	.01	.001	NS
Anti-Fas	48	54 ± 10	52 ± 18	77 ± 26	.01	.01	NS
Anti-Fas ± anti-Ig	18	53 ± 13	49 ± 10	64 ± 12	.05	.05	NS
Anti-Fas ± anti-Ig	48	34 ± 12	31 ± 17	51 ± 7	.01	.01	NS

Treatment	Incubation	Specific Cell Survival %^*			Statistical Analysis^†
	Time (hr)	I	II	III	II v III	I v III	I v II
		Normal Controls^‡	Patients with Chronic ITP	Patients with ALD	P <	P <	P <
		(n = 16)	(n = 12)	(n = 7)
Anti-Fas	18	59 ± 9	56 ± 6	89 ± 17	.01	.001	NS
Anti-Fas	48	54 ± 10	52 ± 18	77 ± 26	.01	.01	NS
Anti-Fas ± anti-Ig	18	53 ± 13	49 ± 10	64 ± 12	.05	.05	NS
Anti-Fas ± anti-Ig	48	34 ± 12	31 ± 17	51 ± 7	.01	.01	NS

Cell death was induced as reported in Fig 2. Results are expressed as means ± SD of the percentage of specific cell survival.

Statistical analysis was performed using the nonparametric Mann-Whitney test.

Age-matched normal controls.