Table 3. Distribution of Mutations in... | American Society of Hematology

Table 3.

Distribution of Mutations in Consensus VH and VL Sequences

Patient	Region	VH Genes
		Expected		Observed		P^3-150	VL Genes
		R	S	R	S		Expected		Observed		P
							R	S	R	S
HA	CDR^3-151	1	0	1	0	.38	2	0	0	2	.10
	FWR	4	1	1	5		5	2	3	5
SM	CDR	4	1	2	5	.14	3	1	2	4	.22
	FWR	13	4	4	11		8	3	3	6
OR	CDR	1	0	2	1	.27	1	0	1	1	.36
	FWR	2	1	0	1		4	1	4	1
RO	CDR	6	1	7	6	.14	4	1	7	4	.05
	FWR	17	6	8	9		11	3	5	3
SH	CDR	2	0	3	1	.17	2	1	2	2	.30
	FWR	5	2	4	1		6	2	5	2

Patient	Region	VH Genes
		Expected		Observed		P^3-150	VL Genes
		R	S	R	S		Expected		Observed		P
							R	S	R	S
HA	CDR^3-151	1	0	1	0	.38	2	0	0	2	.10
	FWR	4	1	1	5		5	2	3	5
SM	CDR	4	1	2	5	.14	3	1	2	4	.22
	FWR	13	4	4	11		8	3	3	6
OR	CDR	1	0	2	1	.27	1	0	1	1	.36
	FWR	2	1	0	1		4	1	4	1
RO	CDR	6	1	7	6	.14	4	1	7	4	.05
	FWR	17	6	8	9		11	3	5	3
SH	CDR	2	0	3	1	.17	2	1	2	2	.30
	FWR	5	2	4	1		6	2	5	2

P is the probability for obtaining the observed number of R mutations in the CDRs by chance.

CDRs encoded by the VH or VL gene segments.