Expression of RET Proto-Oncogene and GDNFR-α in Human Leukemia/Lymphoma Cell Lines
| Lineage . | Cell Line . | Phenotype . | Expression of . | |
|---|---|---|---|---|
| . | . | . | RET . | GDNFR-α . |
| Myelo-monocytic | KG-1 | CD34− early myeloblasts | − | − |
| KG-1A | CD34+ early myeloblasts | + | + | |
| HL-60 | Myeloblasts-Promyelocytes | + | − | |
| NB-4 | Promyelocytes, t(15; 17) | + | − | |
| U937 | Early monoblasts | − | − | |
| ML-3 | Myelo-monoblasts | + | − | |
| THP-1 | Monoblasts | + | − | |
| K562 | Early myelo-erythroblasts | − | − | |
| HEL | Myelo-erythroblasts | − | − | |
| Mo7e | Megakaryoblasts | + | − | |
| FLG 29.1 | Pre-osteoclasts | − | − | |
| T cells | Molt-4 | Thymic (CD4+/CD8+) | − | + |
| FRO | Thymic (CD4+/CD8+) | − | − | |
| Jurkat | Postthymic (CD4+/CD8−) | + | − | |
| CEM | Postthymic (CD4+/CD8−) | − | − | |
| KE-37 | Postthymic (CD4+/CD8−) | + | − | |
| H9 | Mature T (CD4+/CD8−) | + | − | |
| HUT 78 | Mature T (CD4+/CD8−) | + | − | |
| HUT 102 | Mature T (CD4+/CD8−) | − | − | |
| Karpas-299 | Mature T (CD4+/CD8−) | + | − | |
| B cells | BV-173 | Early pre-B (SIg−) | − | − |
| Nalm-6 | Late pre-B (SIg−) | + | + | |
| MN-60 | Early B (SIg+) | − | − | |
| Ci-1 | B-cell lymphoma (SIg+) | − | − | |
| Ri-1 | B-cell lymphoma (SIg+) | − | − | |
| Sc-1 | B-cell lymphoma (SIg+) | − | − | |
| HBL-1 | SNCCL-HIV+ (SIg+) | − | − | |
| HBL-2 | SNCCL-HIV+ (SIg+) | − | − | |
| HBL-3 | SNCCL-HIV+ (SIg+) | − | − | |
| JD38 | sBL (SIg+) | − | − | |
| Namalwa | eBL (SIg+) | − | − | |
| U266 | Plasmacell | − | − | |
| LP-1 | Plasmacell | − | − | |
| IM-9 | Plasmacell | + | − | |
| Lineage . | Cell Line . | Phenotype . | Expression of . | |
|---|---|---|---|---|
| . | . | . | RET . | GDNFR-α . |
| Myelo-monocytic | KG-1 | CD34− early myeloblasts | − | − |
| KG-1A | CD34+ early myeloblasts | + | + | |
| HL-60 | Myeloblasts-Promyelocytes | + | − | |
| NB-4 | Promyelocytes, t(15; 17) | + | − | |
| U937 | Early monoblasts | − | − | |
| ML-3 | Myelo-monoblasts | + | − | |
| THP-1 | Monoblasts | + | − | |
| K562 | Early myelo-erythroblasts | − | − | |
| HEL | Myelo-erythroblasts | − | − | |
| Mo7e | Megakaryoblasts | + | − | |
| FLG 29.1 | Pre-osteoclasts | − | − | |
| T cells | Molt-4 | Thymic (CD4+/CD8+) | − | + |
| FRO | Thymic (CD4+/CD8+) | − | − | |
| Jurkat | Postthymic (CD4+/CD8−) | + | − | |
| CEM | Postthymic (CD4+/CD8−) | − | − | |
| KE-37 | Postthymic (CD4+/CD8−) | + | − | |
| H9 | Mature T (CD4+/CD8−) | + | − | |
| HUT 78 | Mature T (CD4+/CD8−) | + | − | |
| HUT 102 | Mature T (CD4+/CD8−) | − | − | |
| Karpas-299 | Mature T (CD4+/CD8−) | + | − | |
| B cells | BV-173 | Early pre-B (SIg−) | − | − |
| Nalm-6 | Late pre-B (SIg−) | + | + | |
| MN-60 | Early B (SIg+) | − | − | |
| Ci-1 | B-cell lymphoma (SIg+) | − | − | |
| Ri-1 | B-cell lymphoma (SIg+) | − | − | |
| Sc-1 | B-cell lymphoma (SIg+) | − | − | |
| HBL-1 | SNCCL-HIV+ (SIg+) | − | − | |
| HBL-2 | SNCCL-HIV+ (SIg+) | − | − | |
| HBL-3 | SNCCL-HIV+ (SIg+) | − | − | |
| JD38 | sBL (SIg+) | − | − | |
| Namalwa | eBL (SIg+) | − | − | |
| U266 | Plasmacell | − | − | |
| LP-1 | Plasmacell | − | − | |
| IM-9 | Plasmacell | + | − | |
RET expression was detected by RT-PCR.
Abbreviations: GDNFR-α, glial cell line-derived neurotrophic factor; SIg, surface Ig; SNCCL, small noncleaved cell lymphoma; sBL, sporadic Burkitt's lymphoma; eBL, endemic Burkitt's lymphoma.