Expression of RET Proto-Oncogene in Human Lymphoid Hematopoietic Malignancies
| Diagnosis . | Expression of . | |
|---|---|---|
| . | RET . | GNDFR-α . |
| . | (no. positive/no. tested) . | (no. positive/no. tested) . |
| B-cell tumors | 13/85 | 0/60 |
| B-lineage ALL | 2/7 | 0/6 |
| B-CLL | 5/45 | 0/30 |
| B-PLL | 0/2 | 0/1 |
| HCL | 1/7 | 0/5 |
| B-NHL | ||
| HG | 2/9 | 0/6 |
| LG | 2/9 | 0/6 |
| MM | 1/6 | 0/5 |
| T-cell tumors | 3/11 | 1/8 |
| T-ALL | 2/9 | 0/6 |
| T-PLL | 0/1 | 0/1 |
| ATLL | 1/1 | 1/1 |
| Diagnosis . | Expression of . | |
|---|---|---|
| . | RET . | GNDFR-α . |
| . | (no. positive/no. tested) . | (no. positive/no. tested) . |
| B-cell tumors | 13/85 | 0/60 |
| B-lineage ALL | 2/7 | 0/6 |
| B-CLL | 5/45 | 0/30 |
| B-PLL | 0/2 | 0/1 |
| HCL | 1/7 | 0/5 |
| B-NHL | ||
| HG | 2/9 | 0/6 |
| LG | 2/9 | 0/6 |
| MM | 1/6 | 0/5 |
| T-cell tumors | 3/11 | 1/8 |
| T-ALL | 2/9 | 0/6 |
| T-PLL | 0/1 | 0/1 |
| ATLL | 1/1 | 1/1 |
RET expression was detected by RT-PCR.
Abbreviations: GDNFR-α, glial cell line-derived neurotrophic factor; CLL, chronic lymphoblastic leukemia; PLL, prolymphocytic leukemia; HCL, hairy cell leukemia; HG, high grade; LG, low grade; ATLL, adult T-cell leukemia/lymphoma.