Comparison of Heparin and TFAA in the Rabbit Deep Medial Injury Model
| Reagent . | Dose . | n . | % Patency . | CBT . | APTT . | PT . |
|---|---|---|---|---|---|---|
| Saline | 17 | 0 | 1.03 ± 0.26 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| Heparin | 10 U/kg | 5 | 20 | 1.5 ± 0.6 | 1.4 ± 0.2 | 1.0 ± 0.1 |
| 30 U/kg | 5 | 60 | 2.0 ± 0.7 | 3.0 ± 0.4 | 1.1 ± 0.1 | |
| 60 U/kg | 5 | 80 | 2.6 ± 1.2 | 8.9 ± 2.9 | 1.3 ± 0.1 | |
| 90 U/kg | 5 | 100 | 3 ± 1.4 | >18 | 1.6 ± 0.1 | |
| hTFAA | 12.5 mg/kg | 13 | 62 | 1.3 ± 0.7 | 1.1 ± 0.0 | 1.0 ± 0.0 |
| 5 mg/kg | 6 | 16.7 | 1.0 ± 0.44-150 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| rTFAA | 2.0 mg/kg | 4 | 100 | 1.8 ± 0.7 | 1.1 ± 0.0 | 1.1 ± 0.1 |
| Reagent . | Dose . | n . | % Patency . | CBT . | APTT . | PT . |
|---|---|---|---|---|---|---|
| Saline | 17 | 0 | 1.03 ± 0.26 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| Heparin | 10 U/kg | 5 | 20 | 1.5 ± 0.6 | 1.4 ± 0.2 | 1.0 ± 0.1 |
| 30 U/kg | 5 | 60 | 2.0 ± 0.7 | 3.0 ± 0.4 | 1.1 ± 0.1 | |
| 60 U/kg | 5 | 80 | 2.6 ± 1.2 | 8.9 ± 2.9 | 1.3 ± 0.1 | |
| 90 U/kg | 5 | 100 | 3 ± 1.4 | >18 | 1.6 ± 0.1 | |
| hTFAA | 12.5 mg/kg | 13 | 62 | 1.3 ± 0.7 | 1.1 ± 0.0 | 1.0 ± 0.0 |
| 5 mg/kg | 6 | 16.7 | 1.0 ± 0.44-150 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| rTFAA | 2.0 mg/kg | 4 | 100 | 1.8 ± 0.7 | 1.1 ± 0.0 | 1.1 ± 0.1 |
% Patency indicates the fraction of animals that had open carotid arteries for at least 10 minutes during the 40-minute monitoring period. All reagents were given as a bolus injection 2 minutes before vessel damage. Values shown for cuticle bleeding time (CBT), APTT, and PT are the ratio of the value at 1 minute after bolus injection to the value before reagent administration.
CBT was determined at 10 minutes rather than 1 minute after bolus injection.