Reversed Pa Methylation After IFNα, but not Hydroxyurea Treatment
| . | abl Methylation . | Time Interval Between . | ||
|---|---|---|---|---|
| . | First Sample . | Second Sample Pattern/ . | Cytogenetic Response . | Samples (months) . |
| . | Pattern/ . | No. of Patients . | . | . |
| . | No. of Patients . | . | . | . |
| IFNα | ||||
| A | 15 | A 15 | 5/15 | 9.1 ± 4.3 |
| B 0 | ||||
| A 12 | 3/12 | 10.8 ± 6.5 | ||
| B | 14 | B 1 | ||
| C 1 | ||||
| C | 1 | B 1 | ||
| HU | ||||
| A 8 | 0/12 | 11.0 ± 4.5 | ||
| A | 12 | B 2 | ||
| C 2 | ||||
| A 0 | 0/4 | 13.6 ± 4.6 | ||
| B | 4 | B 2 | ||
| C 2 | ||||
| . | abl Methylation . | Time Interval Between . | ||
|---|---|---|---|---|
| . | First Sample . | Second Sample Pattern/ . | Cytogenetic Response . | Samples (months) . |
| . | Pattern/ . | No. of Patients . | . | . |
| . | No. of Patients . | . | . | . |
| IFNα | ||||
| A | 15 | A 15 | 5/15 | 9.1 ± 4.3 |
| B 0 | ||||
| A 12 | 3/12 | 10.8 ± 6.5 | ||
| B | 14 | B 1 | ||
| C 1 | ||||
| C | 1 | B 1 | ||
| HU | ||||
| A 8 | 0/12 | 11.0 ± 4.5 | ||
| A | 12 | B 2 | ||
| C 2 | ||||
| A 0 | 0/4 | 13.6 ± 4.6 | ||
| B | 4 | B 2 | ||
| C 2 | ||||
Two consecutive samples were drawn from patients treated with IFNα with or without hydroxyurea or hydroxyurea alone and assayed for Pa methylation. The cytogenetic response (>30% Ph′ negative cells) was recorded at the time of second sampling, two patients did not undergo second cytogenetic analysis. The mean interval between consecutive sampling is indicated.
Abbreviation: HU, hydroxyurea.