ETV6 Gene Rearrangement as Detected by Southern Blotting and ETV6-CBFA2 as Detected by RT-PCR in Acute Lymphoblastic Leukemia Cases with 12p Abnormalities
| Cytogenetic Abnormality . | ETV6 Rearrangement . | ETV6-CBFA2 Transcript . | ||
|---|---|---|---|---|
| . | Total Evaluated . | No. Rearranged . | Total Evaluated . | No. Positive . |
| One homolog | ||||
| Deletion | 22 | 12 | 13 | 9 |
| Inversion | 1 | 1 | NA | NA |
| Translocation balanced | ||||
| Simple | 10 | 7 | 7 | 4 |
| Complex | 3 | 2 | 3 | 1 |
| Translocation unbalanced | ||||
| Known origin | 3 | 0 | 2 | 0 |
| Unknown origin | 6 | 3 | 4 | 3 |
| Dicentric | ||||
| dic(9; 12) | 6 | 5 | 4 | 4 |
| dic(7; 12) | 2 | 0 | NA | NA |
| dic(random) | 2 | 0 | 1 | 0 |
| Two homologs | ||||
| t/del/inv/i | 9 | 6 | 4 | 4 |
| Total | 64 | 36 (56%) | 38 | 25 (66%) |
| No. of treatment failures | 16 | 4 | 9 | 3 |
| Cytogenetic Abnormality . | ETV6 Rearrangement . | ETV6-CBFA2 Transcript . | ||
|---|---|---|---|---|
| . | Total Evaluated . | No. Rearranged . | Total Evaluated . | No. Positive . |
| One homolog | ||||
| Deletion | 22 | 12 | 13 | 9 |
| Inversion | 1 | 1 | NA | NA |
| Translocation balanced | ||||
| Simple | 10 | 7 | 7 | 4 |
| Complex | 3 | 2 | 3 | 1 |
| Translocation unbalanced | ||||
| Known origin | 3 | 0 | 2 | 0 |
| Unknown origin | 6 | 3 | 4 | 3 |
| Dicentric | ||||
| dic(9; 12) | 6 | 5 | 4 | 4 |
| dic(7; 12) | 2 | 0 | NA | NA |
| dic(random) | 2 | 0 | 1 | 0 |
| Two homologs | ||||
| t/del/inv/i | 9 | 6 | 4 | 4 |
| Total | 64 | 36 (56%) | 38 | 25 (66%) |
| No. of treatment failures | 16 | 4 | 9 | 3 |
Abbreviations: NA, not available; t, translocation; del, deletion; inv, inversion; i, isochromosome.