Effect of Unfractionated Heparin and the LMWH, Tinzaparin, on Dynamic Tetracycline-Based Measurements
| . | Labeled . | Mineral . | Bone Formation . |
|---|---|---|---|
| . | Surface (%) . | Apposition . | Rate Bone-Surface- . |
| . | . | Rate (μm/d) . | Based (μm3/μm2/d) . |
| Baseline | — | — | — |
| Control | 9.4 ± 2.2 | 1.10 ± 0.14 | 10.38 ± 2.61 |
| LMWH (0.5 U/g) | 6.3 ± 1.1 | 1.00 ± 0.09 | 6.30 ± 1.183-150 |
| LMWH (1.0 U/g) | 6.0 ± 0.93-150 | 0.98 ± 0.19 | 5.86 ± 0.943-150 |
| Heparin (0.5 U/g) | 5.5 ± 0.93-150 | 1.03 ± 0.18 | 5.70 ± 1.033-150 |
| Heparin (1.0 U/g) | 4.8 ± 0.73-150 | 0.99 ± 0.14 | 4.76 ± 0.783-150 |
| . | Labeled . | Mineral . | Bone Formation . |
|---|---|---|---|
| . | Surface (%) . | Apposition . | Rate Bone-Surface- . |
| . | . | Rate (μm/d) . | Based (μm3/μm2/d) . |
| Baseline | — | — | — |
| Control | 9.4 ± 2.2 | 1.10 ± 0.14 | 10.38 ± 2.61 |
| LMWH (0.5 U/g) | 6.3 ± 1.1 | 1.00 ± 0.09 | 6.30 ± 1.183-150 |
| LMWH (1.0 U/g) | 6.0 ± 0.93-150 | 0.98 ± 0.19 | 5.86 ± 0.943-150 |
| Heparin (0.5 U/g) | 5.5 ± 0.93-150 | 1.03 ± 0.18 | 5.70 ± 1.033-150 |
| Heparin (1.0 U/g) | 4.8 ± 0.73-150 | 0.99 ± 0.14 | 4.76 ± 0.783-150 |
Rats were injected with either unfractionated heparin or LMWH, at a concentration of either 0.5 or 1.0 U/g for 32 days. One group of rats also served as a control and were given equivalent volumes of saline in place of heparin. All animals received intraperitoneal injections of tetracycline at 10 and 3 days before sacrifice. The percentage of labeled surface covering the cancellous bone surface was then determined as described in Materials and Methods.
P < .005 when compared with control values.