Treatment Outcomes by AML Onset, CD34, MDR1, Cytogenetic Status, and Efflux in 211 Elderly AML Patients
| . | Patients . | Response to Treatment . | |||
|---|---|---|---|---|---|
| . | No. . | % . | CRs . | % CR . | Univariate P Value . |
| AML onset | |||||
| Secondary | 50 | 24 | 12 | 24 | .0005 |
| De novo | 161 | 76 | 83 | 52 | |
| CD34 expression | |||||
| Positive | 138 | 68 | 53 | 38 | .0027 |
| Negative | 66 | 32 | 39 | 59 | |
| MRK16 expression | |||||
| Bright/moderate (+) | 102 | 54 | 35 | 34 | .0019 |
| Dim (+) | 33 | 17 | 15 | 45 | |
| Negative | 54 | 29 | 36 | 67 | |
| Cytogenetic status | |||||
| Unfavorable | 52 | 32 | 11 | 21 | <.0001 |
| Intermediate/favorable | 112 | 68 | 62 | 55 | |
| Functional efflux | |||||
| Positive | 101 | 58 | 35 | 35 | .0039 |
| Negative | 74 | 42 | 43 | 58 | |
| . | Patients . | Response to Treatment . | |||
|---|---|---|---|---|---|
| . | No. . | % . | CRs . | % CR . | Univariate P Value . |
| AML onset | |||||
| Secondary | 50 | 24 | 12 | 24 | .0005 |
| De novo | 161 | 76 | 83 | 52 | |
| CD34 expression | |||||
| Positive | 138 | 68 | 53 | 38 | .0027 |
| Negative | 66 | 32 | 39 | 59 | |
| MRK16 expression | |||||
| Bright/moderate (+) | 102 | 54 | 35 | 34 | .0019 |
| Dim (+) | 33 | 17 | 15 | 45 | |
| Negative | 54 | 29 | 36 | 67 | |
| Cytogenetic status | |||||
| Unfavorable | 52 | 32 | 11 | 21 | <.0001 |
| Intermediate/favorable | 112 | 68 | 62 | 55 | |
| Functional efflux | |||||
| Positive | 101 | 58 | 35 | 35 | .0039 |
| Negative | 74 | 42 | 43 | 58 | |