Identification of D and J Gene Segments Used in the H and L Chains of Anti-Rh(D) MoAbs
| Antibody . | D Segment* . | JH Segment* . | JL Segment* . |
|---|---|---|---|
| 25F5 | D21/9 | JH3a | Jκ1 |
| 13E10 | DN4 | JH6b | Jλ2/Jλ3† |
| 21H9 | DLR4 | JH6c | Jκ4 |
| 28E4 | D21/9 | JH5b | Jκ4 |
| 24A5 | DLR3 | JH6c | JλL |
| 26C1 | DA4 | JH6c | Jκ1 |
| 19A5 | DK4 | JH6b | Jκ2 |
| 43F10 | XP′1 | JH6a/b‡ | Jκ1 |
| 13D2 | DM5 | JH6c | Jκ3 |
| 46E7 | DXP1, DHQ52 | JH6c | Jκ1 |
| Antibody . | D Segment* . | JH Segment* . | JL Segment* . |
|---|---|---|---|
| 25F5 | D21/9 | JH3a | Jκ1 |
| 13E10 | DN4 | JH6b | Jλ2/Jλ3† |
| 21H9 | DLR4 | JH6c | Jκ4 |
| 28E4 | D21/9 | JH5b | Jκ4 |
| 24A5 | DLR3 | JH6c | JλL |
| 26C1 | DA4 | JH6c | Jκ1 |
| 19A5 | DK4 | JH6b | Jκ2 |
| 43F10 | XP′1 | JH6a/b‡ | Jκ1 |
| 13D2 | DM5 | JH6c | Jκ3 |
| 46E7 | DXP1, DHQ52 | JH6c | Jκ1 |
References for the germline genes are as follows: D segments: DN4, DLR4, DLR3, DA4, DK4, XP′1, and DXP149; D21/950; DM551; DHQ5252. JH segments: JH3a and JH6a52; JH6b, JH6c and JH5b are consensus sequences derived from rearranged genes.53 JL segments: Jκ54; Jλ.55
Same gene.
The 43F10 JH segment is highly homologous to both JH6a and JH6b.