Comparative Distribution of pI of VH and VL Segments Available in the Germline Repertoire and Used in Peripheral B Cells and Anti-Rh(D)
| pI Interval . | No. of VH Segments in pI Interval . | ||
|---|---|---|---|
| . | Germline Repertoire . | Peripheral B Cells Usage (% of total)4-150 . | Anti-Rh(D)4-151 . |
| VH | |||
| >10.00 | 5 | 1 (2.8%) | 2 (DP-25, VI-2) |
| 9.66-9.99 | 15 | 10 (36.5%) | 3 (hv3019b9, DP-7, and hv3019b13) |
| 9.33-9.65 | 5 | 4 (8.4%) | 1 (3-21) |
| 9.00-9.32 | 10 | 5 (12.6%) | 0 |
| 8.66-8.99 | 4 | 1 (7.0%) | 0 |
| 8.33-8.65 | 5 | 4 (28.1%) | 0 |
| 8.00-8.32 | 3 | 2 (2.8%) | 0 |
| <8.00 | 4 | 1 (1.4%) | 0 |
| VL | |||
| >9.00 | 2 | — | 0 |
| 8.40-8.99 | 3 | — | 0 |
| 7.80-8.39 | 10 | — | 4(L11, L12a, 02, and DPK21) |
| 7.20-7.79 | 4 | — | 0 |
| 6.60-7.19 | 5 | — | 0 |
| 6.00-6.59 | 8 | — | 1 (Humkv325) |
| 5.40-5.99 | 5 | — | 1 (DPL11) |
| 4.80-5.39 | 8 | — | 1 (IGLV3S1) |
| 4.20-4.79 | 10 | — | 0 |
| <4.20 | 2 | — | 0 |
| pI Interval . | No. of VH Segments in pI Interval . | ||
|---|---|---|---|
| . | Germline Repertoire . | Peripheral B Cells Usage (% of total)4-150 . | Anti-Rh(D)4-151 . |
| VH | |||
| >10.00 | 5 | 1 (2.8%) | 2 (DP-25, VI-2) |
| 9.66-9.99 | 15 | 10 (36.5%) | 3 (hv3019b9, DP-7, and hv3019b13) |
| 9.33-9.65 | 5 | 4 (8.4%) | 1 (3-21) |
| 9.00-9.32 | 10 | 5 (12.6%) | 0 |
| 8.66-8.99 | 4 | 1 (7.0%) | 0 |
| 8.33-8.65 | 5 | 4 (28.1%) | 0 |
| 8.00-8.32 | 3 | 2 (2.8%) | 0 |
| <8.00 | 4 | 1 (1.4%) | 0 |
| VL | |||
| >9.00 | 2 | — | 0 |
| 8.40-8.99 | 3 | — | 0 |
| 7.80-8.39 | 10 | — | 4(L11, L12a, 02, and DPK21) |
| 7.20-7.79 | 4 | — | 0 |
| 6.60-7.19 | 5 | — | 0 |
| 6.00-6.59 | 8 | — | 1 (Humkv325) |
| 5.40-5.99 | 5 | — | 1 (DPL11) |
| 4.80-5.39 | 8 | — | 1 (IGLV3S1) |
| 4.20-4.79 | 10 | — | 0 |
| <4.20 | 2 | — | 0 |