Predicted HLA-A0201 Binding Half-Lives of Peptides Derived From BCR-ABL, ABL, and BCR
| Precursor Protein . | Sequence4-150 . | T1/2 (min) . |
|---|---|---|
| BCR-ABL junctional region only | TGFKQSSKA4-151 | 0.120 |
| BCR-ABL junctional region only | KALQRPVAS | 0.013 |
| ABL and BCR-ABL fusion protein | NLFVALYDFV | 1040 |
| ABL and BCR-ABL fusion protein | NLYTFCVSYV | 2815 |
| BCR and BCR-ABL fusion protein | QQYDCKWYI | 572 |
| BCR and BCR-ABL fusion protein | QLLKDSFMV | 1492 |
| BCR (carboxyl terminal) | NLLTFLFLL | 4006 |
| BCR (carboxy terminal) | FLLDHLKRV‡ | 11,163 |
| Precursor Protein . | Sequence4-150 . | T1/2 (min) . |
|---|---|---|
| BCR-ABL junctional region only | TGFKQSSKA4-151 | 0.120 |
| BCR-ABL junctional region only | KALQRPVAS | 0.013 |
| ABL and BCR-ABL fusion protein | NLFVALYDFV | 1040 |
| ABL and BCR-ABL fusion protein | NLYTFCVSYV | 2815 |
| BCR and BCR-ABL fusion protein | QQYDCKWYI | 572 |
| BCR and BCR-ABL fusion protein | QLLKDSFMV | 1492 |
| BCR (carboxyl terminal) | NLLTFLFLL | 4006 |
| BCR (carboxy terminal) | FLLDHLKRV‡ | 11,163 |
Pairs of sequences, derived from the parent protein, with the highest binding affinity for HLA-A2 as determined from the algorithm of Parker et al.24
K is the unique junctional amino acid encoded by the b3a2 translocation.
The naturally processed self-peptide bound to HLA-A0201 in this study.