Kininogens' Antithrombin, Antiadhesive, and Profibrinolytic Activities
| Domain . | Activity . |
|---|---|
| Bradykinin | Stimulates prostacyclin formation |
| Bradykinin | Stimulates NO formation |
| Bradykinin | Stimulates superoxide formation |
| Bradykinin | Selectively stimulates tissue plasminogen activator secretion |
| RPPGF | Prevents α-thrombin from cleaving its receptor (PAR1) |
| Domain 1 | Inhibits atrial naturetic factor |
| Domain 2 | Prevents calpain-related platelet aggregation |
| Domain 3 | Prevents α-thrombin binding to platelets and endothelial cells |
| Domain 5 | Prevents cells from sticking to artificial surfaces |
| Domain 5 | Displaces fibrinogen from surfaces and cells |
| Domain 6 | Prekallikrein and factor XI receptor on endothelial cells and neutrophils |
| Domain . | Activity . |
|---|---|
| Bradykinin | Stimulates prostacyclin formation |
| Bradykinin | Stimulates NO formation |
| Bradykinin | Stimulates superoxide formation |
| Bradykinin | Selectively stimulates tissue plasminogen activator secretion |
| RPPGF | Prevents α-thrombin from cleaving its receptor (PAR1) |
| Domain 1 | Inhibits atrial naturetic factor |
| Domain 2 | Prevents calpain-related platelet aggregation |
| Domain 3 | Prevents α-thrombin binding to platelets and endothelial cells |
| Domain 5 | Prevents cells from sticking to artificial surfaces |
| Domain 5 | Displaces fibrinogen from surfaces and cells |
| Domain 6 | Prekallikrein and factor XI receptor on endothelial cells and neutrophils |