Experimental Diseases States for Which Contact System Activation Is Pathogenetic
| Disease4-150 . | PK . | HK . | C1 INH . | XI (Act.) . | XII (Act.) . | α2M-Kal Complexes (Ant.) . | C1 INH-Kal Complexes (Ant.) . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Act. . | Ant. . | Act. . | Ant. . | Act. . | Ant. . | . | . | . | . |
| Baboon sepsis278 279 | D | — | D | — | — | — | I | — | I | — |
| Rat arthritis284 286 | D | — | D | — | — | — | D | — | — | — |
| Rat enterocolitis286 287 | D | — | D | — | — | — | D | — | — | — |
| Disease4-150 . | PK . | HK . | C1 INH . | XI (Act.) . | XII (Act.) . | α2M-Kal Complexes (Ant.) . | C1 INH-Kal Complexes (Ant.) . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Act. . | Ant. . | Act. . | Ant. . | Act. . | Ant. . | . | . | . | . |
| Baboon sepsis278 279 | D | — | D | — | — | — | I | — | I | — |
| Rat arthritis284 286 | D | — | D | — | — | — | D | — | — | — |
| Rat enterocolitis286 287 | D | — | D | — | — | — | D | — | — | — |
In these conditions, a role for contact activation in the pathogenesis of these disorders is shown by the finding that specific inhibitors of the contact system blocked the progression of the disease.
Abbreviations: D, decreased; I, increased.
The numbers after the disease category are references.