Outcome After BMT: Multivariate Analysis
| A.Relapse (unfavorable factors) | |||
| RR of Relapse | 95% CI | P | |
| Autologous | 3.12 | 2.17-4.49 | .001 |
| Age > 18 yrs | 1.42 | 1.03-1.95 | .028 |
| Female | 1.29 | 0.95-1.74 | .096 |
| 1991-1993 | 1.46 | 1.06-2.01 | .019 |
| CR1 | 0.59 | 0.38-0.91 | .015 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.46 | 1.02-2.09 | .034 |
| In relapse | 1.46 | 1.06-2.01 | .019 |
| B.Transplant-related mortality (unfavorable factors) | |||
| RR of death in remission | 95% CI | P | |
| URD | 2.83 | 1.88-4.27 | .001 |
| Age > 18 yrs | 1.72 | 1.27-2.33 | .001 |
| Female | 1.37 | 1.02-1.82 | .03 |
| 1987-1990 | 1.13 | 0.82-1.56 | .44 |
| CR1 | 1.21 | 0.78-1.87 | .38 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.66 | 1.14-2.42 | .006 |
| In relapse | 1.6 | 1.06-2.41 | .022 |
| C.Disease-free survival (favorable factors) | |||
| RR of relapse or death | 95% CI | P | |
| URD | 0.91 | 0.71-1.15 | .42 |
| Age ≤ 18 | 0.63 | 0.51-0.78 | .001 |
| Male | 0.76 | 0.61-0.93 | .007 |
| 1987-1990 | 0.88 | 0.71-1.1 | .26 |
| CR1 | 0.87 | 0.64-1.18 | .36 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.57 | 1.21-2.02 | .001 |
| In relapse | 1.74 | 1.29-2.36 | .001 |
| A.Relapse (unfavorable factors) | |||
| RR of Relapse | 95% CI | P | |
| Autologous | 3.12 | 2.17-4.49 | .001 |
| Age > 18 yrs | 1.42 | 1.03-1.95 | .028 |
| Female | 1.29 | 0.95-1.74 | .096 |
| 1991-1993 | 1.46 | 1.06-2.01 | .019 |
| CR1 | 0.59 | 0.38-0.91 | .015 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.46 | 1.02-2.09 | .034 |
| In relapse | 1.46 | 1.06-2.01 | .019 |
| B.Transplant-related mortality (unfavorable factors) | |||
| RR of death in remission | 95% CI | P | |
| URD | 2.83 | 1.88-4.27 | .001 |
| Age > 18 yrs | 1.72 | 1.27-2.33 | .001 |
| Female | 1.37 | 1.02-1.82 | .03 |
| 1987-1990 | 1.13 | 0.82-1.56 | .44 |
| CR1 | 1.21 | 0.78-1.87 | .38 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.66 | 1.14-2.42 | .006 |
| In relapse | 1.6 | 1.06-2.41 | .022 |
| C.Disease-free survival (favorable factors) | |||
| RR of relapse or death | 95% CI | P | |
| URD | 0.91 | 0.71-1.15 | .42 |
| Age ≤ 18 | 0.63 | 0.51-0.78 | .001 |
| Male | 0.76 | 0.61-0.93 | .007 |
| 1987-1990 | 0.88 | 0.71-1.1 | .26 |
| CR1 | 0.87 | 0.64-1.18 | .36 |
| CR2 | 1.0 | — | — |
| CR3+ | 1.57 | 1.21-2.02 | .001 |
| In relapse | 1.74 | 1.29-2.36 | .001 |
Shown are the unfavorable factors (for relapse and transplantrelated mortality) and the favorable factors (for disease-free survival) independently associated with each endpoint in Cox model multivariate analysis. The relative risk, 95% CI and significance probability for each factor considered is shown. For remission number, the relative risks are shown compared with the reference group transplanted during CR2. For year of transplant, the groups are divided 1987-1990; 1991-1993.
Abbreviations: BMT, bone marrow transplantation; RR, relative risk; CI, confidence interval; CR, complete remission; URD, unrelated donor marrow.