Clinical Features of MALT Lymphomas Successfully Examined by Molecular Methods
| Patient . | Age/Sex . | Presentation . | Treatment . | Pathology . | Follow-Up . |
|---|---|---|---|---|---|
| 1 | 39/M | Gastrointestinal bleeding, barium meal showed “carcinoma” | Partial gastrectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes. Spleen 260 g, histologically involved. | Staging negative, radiotherapy, well for 14 yrs. Relapsed with lymphoma in the lung, cervical nodes and bone marrow. Chemotherapy administered, alive and well after 1.5 yrs. |
| 2 | 72/M | Epigastric discomfort, biopsy showed MALT lymphoma. | Partial gastrectomy and splenectomy | Extensive infiltration by low-grade MALT lymphoma of the stomach, gastric lymph nodes involved. Spleen 200 g, histologically involved. | Staging showed liver, marrow involvement. Chemotherapy administered, alive and well at 1.5 yrs. |
| 3 | 59/F | Dyspepsia, biopsy showed chronic gastritis. Gastric perforation, emergency surgery. | Partial gastrectomy, partial jenunectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes, small intestinal deposits. Spleen 200 g, histologically involved. | Staging showed bone marrow involvement. Chemotherapy administered, alive and well. |
| 4 | 63/M | Epigastric pain 4 yrs, biopsy showed MALT lymphoma | Partial gastrectomy, partial jenunectomy and splenectomy | Multifocal mucosal low-grade MALT lymphoma of the stomach, gastric lymph nodes negative, small intestinal deposit. Spleen 120 g, histologically uninvolved. | Chemotherapy administered, well for 2 yrs, then multiple lymphomatous infiltrates in ribs and vertebrae. Lost to follow-up. |
| 5 | 55/F | Epigastric discomfort 10 years, biopsy showed MALT lymphoma | Partial gastrectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes. Spleen 115 g, histologically uninvolved. | Chemotherapy administered, well for 18 mos. Dead of heart failure (?) due to doxorubicin cardiotoxicity. No evidence of recurrent lymphoma; no autopsy. |
| 6 | 64/M | NA | Partial gastrectomy and splenectomy | Low-grade MALT lymphoma, invading up to submucosa, gastric lymph node involved. Coexistence of gastric adenocarcinoma. Spleen normal size, histologically uninvolved. | NA |
| 7 | 74/F | NA | Partial gastrectomy and splenectomy | Predominantly high-grade lymphoma with focal low-grade MALT components, full thickness invasion, gastric lymph node involved. Spleen normal size, histologically uninvolved. | NA |
| 8 | 79/M | Epigastric pain. Endoscopy showed a large gastric ulcer and biopsy showed high-grade NHL. | Partial gastrectomy, partial jenunectomy and splenectomy | Predominantly high-grade lymphoma of the stomach with focal low-grade MALT components, gastric lymph node involved, small intestine deposit. Spleen 145 g, histologically uninvolved. | Staging showed widespread mediastinal lymphadenopathy and patient developed a vocal cord paralysis, chemotherapy administered, pulmonary shadowing (drug-induced alveolar damage?). Died 9 mos after surgery. |
| Patient . | Age/Sex . | Presentation . | Treatment . | Pathology . | Follow-Up . |
|---|---|---|---|---|---|
| 1 | 39/M | Gastrointestinal bleeding, barium meal showed “carcinoma” | Partial gastrectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes. Spleen 260 g, histologically involved. | Staging negative, radiotherapy, well for 14 yrs. Relapsed with lymphoma in the lung, cervical nodes and bone marrow. Chemotherapy administered, alive and well after 1.5 yrs. |
| 2 | 72/M | Epigastric discomfort, biopsy showed MALT lymphoma. | Partial gastrectomy and splenectomy | Extensive infiltration by low-grade MALT lymphoma of the stomach, gastric lymph nodes involved. Spleen 200 g, histologically involved. | Staging showed liver, marrow involvement. Chemotherapy administered, alive and well at 1.5 yrs. |
| 3 | 59/F | Dyspepsia, biopsy showed chronic gastritis. Gastric perforation, emergency surgery. | Partial gastrectomy, partial jenunectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes, small intestinal deposits. Spleen 200 g, histologically involved. | Staging showed bone marrow involvement. Chemotherapy administered, alive and well. |
| 4 | 63/M | Epigastric pain 4 yrs, biopsy showed MALT lymphoma | Partial gastrectomy, partial jenunectomy and splenectomy | Multifocal mucosal low-grade MALT lymphoma of the stomach, gastric lymph nodes negative, small intestinal deposit. Spleen 120 g, histologically uninvolved. | Chemotherapy administered, well for 2 yrs, then multiple lymphomatous infiltrates in ribs and vertebrae. Lost to follow-up. |
| 5 | 55/F | Epigastric discomfort 10 years, biopsy showed MALT lymphoma | Partial gastrectomy and splenectomy | Extensive low-grade MALT lymphoma of the stomach, gastric lymph nodes. Spleen 115 g, histologically uninvolved. | Chemotherapy administered, well for 18 mos. Dead of heart failure (?) due to doxorubicin cardiotoxicity. No evidence of recurrent lymphoma; no autopsy. |
| 6 | 64/M | NA | Partial gastrectomy and splenectomy | Low-grade MALT lymphoma, invading up to submucosa, gastric lymph node involved. Coexistence of gastric adenocarcinoma. Spleen normal size, histologically uninvolved. | NA |
| 7 | 74/F | NA | Partial gastrectomy and splenectomy | Predominantly high-grade lymphoma with focal low-grade MALT components, full thickness invasion, gastric lymph node involved. Spleen normal size, histologically uninvolved. | NA |
| 8 | 79/M | Epigastric pain. Endoscopy showed a large gastric ulcer and biopsy showed high-grade NHL. | Partial gastrectomy, partial jenunectomy and splenectomy | Predominantly high-grade lymphoma of the stomach with focal low-grade MALT components, gastric lymph node involved, small intestine deposit. Spleen 145 g, histologically uninvolved. | Staging showed widespread mediastinal lymphadenopathy and patient developed a vocal cord paralysis, chemotherapy administered, pulmonary shadowing (drug-induced alveolar damage?). Died 9 mos after surgery. |
Abbreviation: NA, not available.