Coagulation and FVII Antigen Indices of the FVII (N57D) Kindred
| Subject . | Exon 4 Genotype . | Laboratory 1* . | Laboratory 2* . | ||
|---|---|---|---|---|---|
| FVII:Ag (%) . | FVII:C (U/mL) . | FVII:Ag (%) . | FVII:C (U/mL) . | ||
| II1 | H | 96 | 0.75 | 97 | 0.71 |
| III2 | H | 102 | 0.67 | 92 | 0.66 |
| III3† | H | 51 | 0.32 | 72 | 0.37 |
| IV3 | H | 86 | 0.57 | 80 | 0.60 |
| Mean‡ | 84 | 0.58 | 85 | 0.59 | |
| Subject . | Exon 4 Genotype . | Laboratory 1* . | Laboratory 2* . | ||
|---|---|---|---|---|---|
| FVII:Ag (%) . | FVII:C (U/mL) . | FVII:Ag (%) . | FVII:C (U/mL) . | ||
| II1 | H | 96 | 0.75 | 97 | 0.71 |
| III2 | H | 102 | 0.67 | 92 | 0.66 |
| III3† | H | 51 | 0.32 | 72 | 0.37 |
| IV3 | H | 86 | 0.57 | 80 | 0.60 |
| Mean‡ | 84 | 0.58 | 85 | 0.59 | |
Abbreviation: H, heterozygous.
Experiments were performed on both identical fresh plasma samples and a single lot of normal pooled plasma by two independent laboratories. All values are compared to normal pooled plasma which was assigned values of 100% FVII:Ag and 1 unit/ml FVII:C activity.
Propositus.
The mean of FVII antigen and coagulant activities from affected family members.