Three-Year Outcome of Bone Marrow Transplants for AML in CR1 According to the Karyotype at Diagnosis
| Karyotype . | . | Relapse (SE) . | LFS (SE) . | Survival (SE) . |
|---|---|---|---|---|
| abn (16) | AlloBMT (n = 20) | 0.06 (0.05) | 0.74 (0.09) | 0.74 (0.09) |
| ABMT (n = 25) | 0.47 (0.10) | 0.51 (0.11) | 0.61 (0.12) | |
| P | .007 | .04 | NS | |
| t(15; 17) | AlloBMT (n = 44) | 0.33 (0.08) | 0.51 (0.07) | 0.53 (0.07) |
| ABMT (n = 36) | 0.28 (0.08) | 0.70 (0.08) | 0.83 (0.06) | |
| P | NS | NS | .02 | |
| t(8; 21) | AlloBMT (n = 47) | 0.11 (0.05) | 0.64 (0.04) | 0.65 (0.07) |
| ABMT (n = 49) | 0.48 (0.08) | 0.46 (0.07) | 0.58 (0.07) | |
| P | .001 | NS | NS | |
| abn 5 and/or 7 | AlloBMT (n = 19) | 0.83 (0.14) | 0.09 (0.08) | 0.22 (0.09) |
| ABMT (n = 31) | 0.77 (0.08) | 0.21 (0.07) | 0.26 (0.09) | |
| P | NS | NS | NS | |
| abn 11q | AlloBMT (n = 18) | 0.55 (0.12) | 0.41 (0.12) | 0.42 (0.12) |
| ABMT (n = 15) | 0.28 (0.12) | 0.66 (0.12) | 0.66 (0.12) | |
| P | NS | NS | NS | |
| Pseudodiploid | AlloBMT (n = 31) | 0.30 (0.10) | 0.46 (0.09) | 0.51 (0.10) |
| ABMT (n = 41) | 0.62 (0.09) | 0.37 (0.09) | 0.49 (0.09) | |
| P | .04 | NS | NS | |
| Hypodiploid | AlloBMT (n = 12) | 0.36 (0.17) | 0.46 (0.15) | 0.38 (0.18) |
| ABMT (n = 12) | 0.78 (0.13) | 0.20 (0.11) | 0.35 (0.15) | |
| P | NS | NS | NS | |
| Hyperdiploid | AlloBMT (n = 48) | 0.17 (0.06) | 0.53 (0.07) | 0.52 (0.07) |
| ABMT (n = 48) | 0.54 (0.08) | 0.39 (0.07) | 0.45 (0.08) | |
| P | .006 | NS | NS | |
| Diploid | AlloBMT (n = 223) | 0.24 (0.03) | 0.60 (0.03) | 0.62 (0.03) |
| ABMT (n = 208) | 0.45 (0.03) | 0.47 (0.03) | 0.49 (0.03) | |
| P | .00004 | .02 | .03 |
| Karyotype . | . | Relapse (SE) . | LFS (SE) . | Survival (SE) . |
|---|---|---|---|---|
| abn (16) | AlloBMT (n = 20) | 0.06 (0.05) | 0.74 (0.09) | 0.74 (0.09) |
| ABMT (n = 25) | 0.47 (0.10) | 0.51 (0.11) | 0.61 (0.12) | |
| P | .007 | .04 | NS | |
| t(15; 17) | AlloBMT (n = 44) | 0.33 (0.08) | 0.51 (0.07) | 0.53 (0.07) |
| ABMT (n = 36) | 0.28 (0.08) | 0.70 (0.08) | 0.83 (0.06) | |
| P | NS | NS | .02 | |
| t(8; 21) | AlloBMT (n = 47) | 0.11 (0.05) | 0.64 (0.04) | 0.65 (0.07) |
| ABMT (n = 49) | 0.48 (0.08) | 0.46 (0.07) | 0.58 (0.07) | |
| P | .001 | NS | NS | |
| abn 5 and/or 7 | AlloBMT (n = 19) | 0.83 (0.14) | 0.09 (0.08) | 0.22 (0.09) |
| ABMT (n = 31) | 0.77 (0.08) | 0.21 (0.07) | 0.26 (0.09) | |
| P | NS | NS | NS | |
| abn 11q | AlloBMT (n = 18) | 0.55 (0.12) | 0.41 (0.12) | 0.42 (0.12) |
| ABMT (n = 15) | 0.28 (0.12) | 0.66 (0.12) | 0.66 (0.12) | |
| P | NS | NS | NS | |
| Pseudodiploid | AlloBMT (n = 31) | 0.30 (0.10) | 0.46 (0.09) | 0.51 (0.10) |
| ABMT (n = 41) | 0.62 (0.09) | 0.37 (0.09) | 0.49 (0.09) | |
| P | .04 | NS | NS | |
| Hypodiploid | AlloBMT (n = 12) | 0.36 (0.17) | 0.46 (0.15) | 0.38 (0.18) |
| ABMT (n = 12) | 0.78 (0.13) | 0.20 (0.11) | 0.35 (0.15) | |
| P | NS | NS | NS | |
| Hyperdiploid | AlloBMT (n = 48) | 0.17 (0.06) | 0.53 (0.07) | 0.52 (0.07) |
| ABMT (n = 48) | 0.54 (0.08) | 0.39 (0.07) | 0.45 (0.08) | |
| P | .006 | NS | NS | |
| Diploid | AlloBMT (n = 223) | 0.24 (0.03) | 0.60 (0.03) | 0.62 (0.03) |
| ABMT (n = 208) | 0.45 (0.03) | 0.47 (0.03) | 0.49 (0.03) | |
| P | .00004 | .02 | .03 |
Abbreviations: AML, acute myeloblastic leukemia; CR1, first complete remission; SE, standard error of the mean; LFS, leukemia-free survival; AlloBMT, allogeneic bone marrow transplantation; ABMT, autologous bone marrow transplantation.