Day 7 GI Tract Damage
| . | Conditioning Regimen . | ||
|---|---|---|---|
| . | 1,300 cGy TBI Syngeneic . | 900 cGy TBI Allogeneic (n = 4) . | 1,300 cGy TBI Allogeneic . |
| . | (n = 2) . | . | (n = 4) . |
| Small bowel* | 2.0 ± 0.5 | 4.0 ± 1.3 | 10.9 ± 1.9† |
| Large bowel‡ | 4.0 ± 1.0 | 4.6 ± 0.7 | 7.6 ± 0.6† |
| . | Conditioning Regimen . | ||
|---|---|---|---|
| . | 1,300 cGy TBI Syngeneic . | 900 cGy TBI Allogeneic (n = 4) . | 1,300 cGy TBI Allogeneic . |
| . | (n = 2) . | . | (n = 4) . |
| Small bowel* | 2.0 ± 0.5 | 4.0 ± 1.3 | 10.9 ± 1.9† |
| Large bowel‡ | 4.0 ± 1.0 | 4.6 ± 0.7 | 7.6 ± 0.6† |
Scores (0-4) for each parameter below were given to coded slides and summed.
Villous blunting, crypt regeneration, loss of enterocyte brush border, luminal sloughing of cellular debri, crypt cell apoptosis, outright crypt destruction, and lamina propria lymphocytic infiltrate.
P < .03 v 900 cGy TBI allo.
Crypt regeneration, surface colonocytes, colonocyte vacuolization, surface colonocyte attenuation, crypt cell apoptosis, outright crypt destruction, and lamina propria lymphocytic infiltrate.