Toxicity Profile of SDZ MRL 953
| . | Side effects of SDZ MRL 953 . | |||||
|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . |
| Dose of SDZ MRL 953 (μg/kg) | Cont | 18.0 | 23.4 | 28.8 | 34.2 | 39.6 |
| No. of patients | 5 | 3 | 3 | 3 | 3 | 3 |
| Fever* | ||||||
| WHO grade 0 | 4 | — | 2 | 1 | — | 1 |
| WHO grade 1 | 1 | 2 | — | — | 2 | — |
| WHO grade 2 | — | 1 | — | 1 | 1 | 2 |
| WHO grade 3 | — | — | 1 | 1 | — | — |
| Hepatic toxicity† | ||||||
| WHO grade 0 | 5 | 3 | 1 | 2 | 1 | 1 |
| WHO grade 1 | — | — | 1 | 1 | 2 | 1 |
| WHO grade 2 | — | — | 1 | — | — | 1 |
| Renal toxicity‡ | ||||||
| WHO grade 0 | 5 | 3 | 3 | 3 | 3 | 3 |
| Nausea | 1 | — | 1 | 1 | — | 1 |
| Hypertension | — | — | 1 | 1 | — | 1 |
| Chills | — | — | 1 | 1 | — | 1 |
| Fatigue | 2 | 2 | 3 | 2 | 2 | 1 |
| Headache | — | 1 | 1 | 1 | — | 1 |
| Myalgia | — | 1 | 1 | — | — | 1 |
| . | Side effects of SDZ MRL 953 . | |||||
|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . |
| Dose of SDZ MRL 953 (μg/kg) | Cont | 18.0 | 23.4 | 28.8 | 34.2 | 39.6 |
| No. of patients | 5 | 3 | 3 | 3 | 3 | 3 |
| Fever* | ||||||
| WHO grade 0 | 4 | — | 2 | 1 | — | 1 |
| WHO grade 1 | 1 | 2 | — | — | 2 | — |
| WHO grade 2 | — | 1 | — | 1 | 1 | 2 |
| WHO grade 3 | — | — | 1 | 1 | — | — |
| Hepatic toxicity† | ||||||
| WHO grade 0 | 5 | 3 | 1 | 2 | 1 | 1 |
| WHO grade 1 | — | — | 1 | 1 | 2 | 1 |
| WHO grade 2 | — | — | 1 | — | — | 1 |
| Renal toxicity‡ | ||||||
| WHO grade 0 | 5 | 3 | 3 | 3 | 3 | 3 |
| Nausea | 1 | — | 1 | 1 | — | 1 |
| Hypertension | — | — | 1 | 1 | — | 1 |
| Chills | — | — | 1 | 1 | — | 1 |
| Fatigue | 2 | 2 | 3 | 2 | 2 | 1 |
| Headache | — | 1 | 1 | 1 | — | 1 |
| Myalgia | — | 1 | 1 | — | — | 1 |