Expression of HOXC4, HOXC5, and HOXC6 in B-Cell Lymphomas, Classified According to Updated Kiel Classification With Some Modifications According to the REAL Classification
| Case No. . | Biopsy Site . | RISH . | RT-PCR . | ||||
|---|---|---|---|---|---|---|---|
| . | . | C4 . | C5 . | C6 . | C4 . | C5 . | C6 . |
| Burkitt | |||||||
| 1 | LN abdomen | + | − | + | |||
| Lymphoblastic lymphoma | |||||||
| 2 | Subcutaneous presternal | + | − | + | |||
| 3 | LN supraclavicular | + | − | + | |||
| 4 | LN inguinal | + | − | + | |||
| 5 | Gut sigmoid | NE | − | + | + | − | + |
| B-lymphocytic B-CLL | |||||||
| 6 | LN armpit | + | − | − | |||
| 7 | LN neck | + | − | − | + | + | + |
| 8 | LN neck | + | − | − | |||
| 9 | LN armpit | + | − | − | |||
| 10 | LN armpit | + | − | − | |||
| Mantle cell lymphoma | |||||||
| 11 | Tonsil | + | − | − | + | + | + |
| Centroblastic/centrocytic diffuse | |||||||
| 12 | Skin ear | + | − | + | |||
| 13 | Subcutaneous scapula | + | − | + | + | + | + |
| 14 | Subcutaneous hip | + | − | + | + | + | + |
| 15 | LN armpit | + | − | + | |||
| 16 | LN neck | + | − | + | |||
| 17 | LN neck | + | − | + | |||
| 18 | LN neck | + | − | + | |||
| Centroblastic/centrocytic follicular | |||||||
| 19 | LN supraclavicular | + | − | + | + | + | + |
| 20 | LN inguinal | + | − | + | + | + | + |
| Centroblastic lymphoma | |||||||
| 21 | Skin low leg | + | − | + | |||
| 22 | LN neck | + | + | + | + | + | + |
| 23 | Nasopharynx | + | ± | + | |||
| 24 | Stomach | + | − | + | |||
| 25 | Gut jejunum/ileum | + | − | + | |||
| 25 | Gut ileum | + | − | + | |||
| 26 | Gut coecum | + | − | + | |||
| Immunoblastic lymphoma | |||||||
| 27 | Skin back | + | − | + | |||
| 28 | LN neck | + | − | ± | |||
| 29 | Rectum | + | ± | + | |||
| Lymphoplasmacytic immunocytoma | |||||||
| 30 | Skin lip* | + | + | − | |||
| 31 | LN para-aorta | + | − | + | |||
| 32 | LN para-aorta | + | + | + | + | + | + |
| 33 | LN supraclavicular | + | NE | NE | + | + | + |
| 34 | LN armpit | + | + | + | |||
| 35 | LN iliaca | + | − | − | + | + | + |
| 36 | LN inguinal | + | − | + | |||
| 37 | Spleen | + | − | + | + | + | + |
| Extranodal marginal zone B-cell lymphoma (maltoma) | |||||||
| 38 | LN in parotis | + | + | + | + | + | + |
| 39 | Parotis | + | ± | ± | + | + | + |
| 40 | Mucosa nasal | + | − | − | + | − | − |
| 41 | Tonsil | + | + | + | + | + | + |
| 42 | Stomach | − | − | + | |||
| 43 | Stomach | + | + | + | |||
| 44 | Stomach | + | ± | + | |||
| 45 | Colon | + | + | + | |||
| 46 | Bone marrow | + | + | + | |||
| Normal lymphoid tissues | |||||||
| 47 | Thymus | + | − | + | + | − | + |
| 48-51 | LN neck | + | − | + | |||
| 52 | LN stomach | + | − | + | |||
| 53 | LN spleen | + | − | + | |||
| 54-61 | Tonsil | + | − | + | + | − | + |
| 62-67 | PBMC | + | − | + | |||
| Case No. . | Biopsy Site . | RISH . | RT-PCR . | ||||
|---|---|---|---|---|---|---|---|
| . | . | C4 . | C5 . | C6 . | C4 . | C5 . | C6 . |
| Burkitt | |||||||
| 1 | LN abdomen | + | − | + | |||
| Lymphoblastic lymphoma | |||||||
| 2 | Subcutaneous presternal | + | − | + | |||
| 3 | LN supraclavicular | + | − | + | |||
| 4 | LN inguinal | + | − | + | |||
| 5 | Gut sigmoid | NE | − | + | + | − | + |
| B-lymphocytic B-CLL | |||||||
| 6 | LN armpit | + | − | − | |||
| 7 | LN neck | + | − | − | + | + | + |
| 8 | LN neck | + | − | − | |||
| 9 | LN armpit | + | − | − | |||
| 10 | LN armpit | + | − | − | |||
| Mantle cell lymphoma | |||||||
| 11 | Tonsil | + | − | − | + | + | + |
| Centroblastic/centrocytic diffuse | |||||||
| 12 | Skin ear | + | − | + | |||
| 13 | Subcutaneous scapula | + | − | + | + | + | + |
| 14 | Subcutaneous hip | + | − | + | + | + | + |
| 15 | LN armpit | + | − | + | |||
| 16 | LN neck | + | − | + | |||
| 17 | LN neck | + | − | + | |||
| 18 | LN neck | + | − | + | |||
| Centroblastic/centrocytic follicular | |||||||
| 19 | LN supraclavicular | + | − | + | + | + | + |
| 20 | LN inguinal | + | − | + | + | + | + |
| Centroblastic lymphoma | |||||||
| 21 | Skin low leg | + | − | + | |||
| 22 | LN neck | + | + | + | + | + | + |
| 23 | Nasopharynx | + | ± | + | |||
| 24 | Stomach | + | − | + | |||
| 25 | Gut jejunum/ileum | + | − | + | |||
| 25 | Gut ileum | + | − | + | |||
| 26 | Gut coecum | + | − | + | |||
| Immunoblastic lymphoma | |||||||
| 27 | Skin back | + | − | + | |||
| 28 | LN neck | + | − | ± | |||
| 29 | Rectum | + | ± | + | |||
| Lymphoplasmacytic immunocytoma | |||||||
| 30 | Skin lip* | + | + | − | |||
| 31 | LN para-aorta | + | − | + | |||
| 32 | LN para-aorta | + | + | + | + | + | + |
| 33 | LN supraclavicular | + | NE | NE | + | + | + |
| 34 | LN armpit | + | + | + | |||
| 35 | LN iliaca | + | − | − | + | + | + |
| 36 | LN inguinal | + | − | + | |||
| 37 | Spleen | + | − | + | + | + | + |
| Extranodal marginal zone B-cell lymphoma (maltoma) | |||||||
| 38 | LN in parotis | + | + | + | + | + | + |
| 39 | Parotis | + | ± | ± | + | + | + |
| 40 | Mucosa nasal | + | − | − | + | − | − |
| 41 | Tonsil | + | + | + | + | + | + |
| 42 | Stomach | − | − | + | |||
| 43 | Stomach | + | + | + | |||
| 44 | Stomach | + | ± | + | |||
| 45 | Colon | + | + | + | |||
| 46 | Bone marrow | + | + | + | |||
| Normal lymphoid tissues | |||||||
| 47 | Thymus | + | − | + | + | − | + |
| 48-51 | LN neck | + | − | + | |||
| 52 | LN stomach | + | − | + | |||
| 53 | LN spleen | + | − | + | |||
| 54-61 | Tonsil | + | − | + | + | − | + |
| 62-67 | PBMC | + | − | + | |||
Abbreviations: LN, lymph node; NE, not evaluable; PBMC, peripheral blood mononuclear cells; +, strong staining with RISH; ±, weak staining with RISH; −, no staining with RISH.
No paraffin-embedded material available for RISH.