Expression of MHC Class-I and -II and Signaling or Costimulatory Molecules on Noninduced and Cytokine-Induced Bone Marrow CD38++ Plasma Cells
| . | Noninduced . | IFN-γ–Induced . | TNF-α–Induced . | Interleukin-6–Induced . | |||
|---|---|---|---|---|---|---|---|
| . | MFI . | MFI . | Ratio* . | MFI . | Ratio* . | MFI . | Ratio* . |
| HLA-DR | 497 (417-518) | 1,019 (686-1,615) | 2.1 | 840 (320-1,219) | 1.7 | 540 (440-640) | 1.1 |
| HLA-DQ | 300 (270-340) | 716 (560-890) | 2.4 | 490 (402-550) | 1.6 | 334 (302-390) | 1.1 |
| HLA-ABC | 1,444 (1,217-2,124) | 3,719 (2,535-4,835) | 2.6 | 2,998 (1,332-5,001) | 2.1 | 2,077 (1,211-2,944) | 1.4 |
| CD40 | 175 (146-165) | 278 (125-280) | 1.6 | 176 (120-227) | 1.1 | 141 (120-160) | 0.8 |
| CD80 | 135 (107-163) | 286 (114-286) | 2.1 | 273 (92-437) | 2.0 | 142 (112-172) | 1.1 |
| CD86 | 180 (156-209) | 393 (226-407) | 2.2 | 246 (198-279) | 1.4 | 257 (229-285) | 1.4 |
| . | Noninduced . | IFN-γ–Induced . | TNF-α–Induced . | Interleukin-6–Induced . | |||
|---|---|---|---|---|---|---|---|
| . | MFI . | MFI . | Ratio* . | MFI . | Ratio* . | MFI . | Ratio* . |
| HLA-DR | 497 (417-518) | 1,019 (686-1,615) | 2.1 | 840 (320-1,219) | 1.7 | 540 (440-640) | 1.1 |
| HLA-DQ | 300 (270-340) | 716 (560-890) | 2.4 | 490 (402-550) | 1.6 | 334 (302-390) | 1.1 |
| HLA-ABC | 1,444 (1,217-2,124) | 3,719 (2,535-4,835) | 2.6 | 2,998 (1,332-5,001) | 2.1 | 2,077 (1,211-2,944) | 1.4 |
| CD40 | 175 (146-165) | 278 (125-280) | 1.6 | 176 (120-227) | 1.1 | 141 (120-160) | 0.8 |
| CD80 | 135 (107-163) | 286 (114-286) | 2.1 | 273 (92-437) | 2.0 | 142 (112-172) | 1.1 |
| CD86 | 180 (156-209) | 393 (226-407) | 2.2 | 246 (198-279) | 1.4 | 257 (229-285) | 1.4 |
Median and range (in parentheses) of MFI are shown. Data were obtained from experiments using BMMCs from four different MM patients.
Ratio was calculated from the median value of MFI from cytokine-induced cells divided by the median of MFI from noninduced cells.