Table 3. Stimulation of AML Blast... | American Society of Hematology

Table 3.

Stimulation of AML Blast Proliferation by Various Cytokines

Cytokine(s)^3-150	Proportion of AML Samples Responding	Fold↑ ³H-Tdr Incorporation^3-151
	% (no. tested)	Median (range)
IL-3	79 (53)	4 (1-126)
GM-CSF	67 (49)	5 (1-51)
G-CSF	50 (50)	1 (1-23)
IL-6	0 (7)	1
SF	63 (48)	2 (1-65)
IL-11	68 (44)	1 (1-19)
IL-1	54 (41)	2 (1-83)
IL-2	43 (35)	1 (1-11)
FL	62 (26)	2 (1-57)
IL-3 + SF	96 (46)	11 (1-253)
IL-3 + FL	96 (26)	10 (1-99)
SF + FL	91 (23)	4 (1-118)
SF + IL-3 + FL	96 (24)	16 (1-122)

Cytokine(s)^3-150	Proportion of AML Samples Responding	Fold↑ ³H-Tdr Incorporation^3-151
	% (no. tested)	Median (range)
IL-3	79 (53)	4 (1-126)
GM-CSF	67 (49)	5 (1-51)
G-CSF	50 (50)	1 (1-23)
IL-6	0 (7)	1
SF	63 (48)	2 (1-65)
IL-11	68 (44)	1 (1-19)
IL-1	54 (41)	2 (1-83)
IL-2	43 (35)	1 (1-11)
FL	62 (26)	2 (1-57)
IL-3 + SF	96 (46)	11 (1-253)
IL-3 + FL	96 (26)	10 (1-99)
SF + FL	91 (23)	4 (1-118)
SF + IL-3 + FL	96 (24)	16 (1-122)

Cytokines tested at final concentrations of 40 ng/mL for IL-3, GM-CSF, G-CSF, IL-6, IL-11, and IL-1 and 100 ng/mL for SF, IL-2, and FL.

As compared with control cultures without cytokines.