Expression of BCL-6 Protein and CD138/syndecan-1 (syn-1) Throughout the Pathologic Spectrum of AIDS-Related NHLs
| Samples . | . | Phenotype* . | ||
|---|---|---|---|---|
| BCL-6+/syn-1− . | BCL-6−/syn-1+ . | BCL-6−/syn-1− . | ||
| Primary samples | ||||
| Systemic AIDS-NHL | ||||
| AIDS-SNCCL | (n = 11) | 11 | 0 | 0 |
| AIDS-LNCCL | (n = 7) | 7 | 0 | 0 |
| AIDS-IBLP | (n = 9) | 2 | 6 | 1 |
| AIDS-PCNSL | ||||
| AIDS-LNCCL | (n = 4) | 4 | 0 | 0 |
| AIDS-IBLP | (n = 4) | 0 | 2 | 2 |
| AIDS-PEL | (n = 5) | 0 | 5 | 0 |
| Cell lines | ||||
| AIDS-PEL | (n = 6) | 0 | 6 | 0 |
| Samples . | . | Phenotype* . | ||
|---|---|---|---|---|
| BCL-6+/syn-1− . | BCL-6−/syn-1+ . | BCL-6−/syn-1− . | ||
| Primary samples | ||||
| Systemic AIDS-NHL | ||||
| AIDS-SNCCL | (n = 11) | 11 | 0 | 0 |
| AIDS-LNCCL | (n = 7) | 7 | 0 | 0 |
| AIDS-IBLP | (n = 9) | 2 | 6 | 1 |
| AIDS-PCNSL | ||||
| AIDS-LNCCL | (n = 4) | 4 | 0 | 0 |
| AIDS-IBLP | (n = 4) | 0 | 2 | 2 |
| AIDS-PEL | (n = 5) | 0 | 5 | 0 |
| Cell lines | ||||
| AIDS-PEL | (n = 6) | 0 | 6 | 0 |
Abbreviations: syn-1, CD138/syndecan-1; SNCCL, small noncleaved cell lymphoma; LNCCL, large noncleaved cell lymphoma; IBLP, immunoblastic lymphoma plasmacytoid; PCNSL, primary central nervous system lymphoma; PEL, primary effusion lymphoma.
None of the AIDS-NHL samples displayed the BLC-6+/syn-1+ phenotype.