CyA Toxicity Against ALL Cell Lines
| Cell Line . | % Cell Kill With Increasing Concentration of CyA (μmol/L) . | |||
|---|---|---|---|---|
| 1 . | 2 . | 5 . | 10 . | |
| B-lineage ALL | ||||
| OP-1 | 16 | 34 | 69 | 98 |
| SUP-B15 | 34 | 39 | 78 | >99 |
| KOPN-55bi | 22 | 44 | 59 | >99 |
| RS4;11 | 35 | 35 | 71 | 98 |
| NALM6 | 55 | 73 | 85 | >99 |
| REH | 25 | 25 | 64 | 99 |
| 380 | 20 | 62 | 69 | 90 |
| T-lineage ALL | ||||
| MOLT4 | 32 | 37 | 58 | 88 |
| CCRF-CEM | 6 | 24 | 85 | >99 |
| CEM-C7 | 3 | 10 | 47 | 95 |
| Cell Line . | % Cell Kill With Increasing Concentration of CyA (μmol/L) . | |||
|---|---|---|---|---|
| 1 . | 2 . | 5 . | 10 . | |
| B-lineage ALL | ||||
| OP-1 | 16 | 34 | 69 | 98 |
| SUP-B15 | 34 | 39 | 78 | >99 |
| KOPN-55bi | 22 | 44 | 59 | >99 |
| RS4;11 | 35 | 35 | 71 | 98 |
| NALM6 | 55 | 73 | 85 | >99 |
| REH | 25 | 25 | 64 | 99 |
| 380 | 20 | 62 | 69 | 90 |
| T-lineage ALL | ||||
| MOLT4 | 32 | 37 | 58 | 88 |
| CCRF-CEM | 6 | 24 | 85 | >99 |
| CEM-C7 | 3 | 10 | 47 | 95 |
Data are the mean of duplicate 4-day culture experiments. Intraassay variability was <5% in all experiments.