Total No. of Hematopoietic Progenitors in fit1 Mice and Wild-Type Littermates
| Tissue . | . | Total Cells . | CFU-E . | BFU-E . | CFU-GM . |
|---|---|---|---|---|---|
| . | . | (×106) . | (×104) . | (×103) . | (×103) . |
| Spleen | + (7) | 180.4 ± 19.2 | 7.6 ± 1.8 | 2.9 ± 1.2 | 21.0 ± 1.5 |
| m (8) | 247.9* ± 81.3 | 1.0 ± 0.4 | 0.1 ± 0.1 | 9.4 ± 2.3 | |
| Bone marrow† | + (7) | 43.7 ± 15.6 | 26.0 ± 1.5 | 12.0 ± 1.6 | 110.0 ± 8.9 |
| m (8) | 17.2 ± 5.6 | 1.9 ± 0.5 | 0.8 ± 0.4 | 19.0 ± 4.0 | |
| E14.5 liver | + (6) | 28.3 ± 11.8 | 27.0 ± 1.3 | 6.1 ± 1.0 | 46.0 ± 7.5 |
| m (5) | 14.2 ± 11.6 | 5.3 ± 2.3 | 0.4 ± 0.2 | 12.0 ± 3.0 |
| Tissue . | . | Total Cells . | CFU-E . | BFU-E . | CFU-GM . |
|---|---|---|---|---|---|
| . | . | (×106) . | (×104) . | (×103) . | (×103) . |
| Spleen | + (7) | 180.4 ± 19.2 | 7.6 ± 1.8 | 2.9 ± 1.2 | 21.0 ± 1.5 |
| m (8) | 247.9* ± 81.3 | 1.0 ± 0.4 | 0.1 ± 0.1 | 9.4 ± 2.3 | |
| Bone marrow† | + (7) | 43.7 ± 15.6 | 26.0 ± 1.5 | 12.0 ± 1.6 | 110.0 ± 8.9 |
| m (8) | 17.2 ± 5.6 | 1.9 ± 0.5 | 0.8 ± 0.4 | 19.0 ± 4.0 | |
| E14.5 liver | + (6) | 28.3 ± 11.8 | 27.0 ± 1.3 | 6.1 ± 1.0 | 46.0 ± 7.5 |
| m (5) | 14.2 ± 11.6 | 5.3 ± 2.3 | 0.4 ± 0.2 | 12.0 ± 3.0 |
The mean total number of cells per organ listed and hematopoietic progenitors listed are shown for wild-type littermates (+) and for c fit14397B/c26DVT mutants (m). The number of mice in each group is shown in parentheses.
The mean of the mutant spleen cellularity is not significantly different from the mean cellularity of control spleens.
The values for bone marrow reflect the total number of cells and progenitors derived from one tibia and one femur from each animal.