Dose-Response Relationship of Crotalin on the Elapsed Time of Inducing Thrombus Formation on Light Irradiation of Venules of Mice Pretreated With Fluorescein Sodium (150 μg per mouse)
| Dose of Crotalin (μg/kg) . | Occlusion Time (s) . | |
|---|---|---|
| Saline . | Crotalin . | |
| 100 | 94 ± 7 (4) | 161 ± 28 (4)* |
| 200 | 97 ± 20 (4) | 273 ± 15 (4)† |
| 300 | 99 ± 19 (4) | 317 ± 31 (5)† |
| Dose of Crotalin (μg/kg) . | Occlusion Time (s) . | |
|---|---|---|
| Saline . | Crotalin . | |
| 100 | 94 ± 7 (4) | 161 ± 28 (4)* |
| 200 | 97 ± 20 (4) | 273 ± 15 (4)† |
| 300 | 99 ± 19 (4) | 317 ± 31 (5)† |
The occlusion time was expressed (in seconds) as the time lapse for inducing platelet-rich thrombus formation on the irradiation of the venules in fluorescein sodium-treated mice. The significant difference of elapsed time was compared between groups before and after administration of crotalin. Values are presented as mean ± SEM (n).
P < .05.
P < .001.