Parameters of Tumor Growth Affected by Timp-1 Expression
| . | Experiment 1 . | Experiment 2 . | Experiment 3 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Timp-1high . | Control . | Timp-1low . | Control . | Timp-1high . | Control . | Timp-1low . | Control . | Timp-1high . | Control . | Timp-1low . | Control . |
| Primary tumor | ||||||||||||
| Tumor take | 3/5 | 5/5 | 5/5 | 5/5 | 4/5 | 2/2 | 4/4 | 3/3 | 3/3 | 2/2 | 2/2 | 3/3 |
| Tumors after rechallenge | 0/2 | — | — | — | 0/1 | — | — | — | — | — | — | — |
| DAI to tumor diameter 8.5 mm | 34 | 21 | 16 | 21 | 31 | 20 | 15 | 21 | 33 | 21 | 16 | 22 |
| t50 survival | 45 | 32 | 26 | 32 | 42 | 30 | 26 | 31 | 45 | 31 | 27 | 32 |
| Spontaneous metastasis | ||||||||||||
| Periportal localization | 3/3 | 5/5 | 2/5 | 5/5 | 4/4 | 2/2 | 1/4 | 3/3 | ND | |||
| Diffuse infiltration | 0/3 | 0/5 | 3/5 | 0/5 | 0/4 | 0/2 | 3/4 | 0/3 | ND | |||
| . | Experiment 1 . | Experiment 2 . | Experiment 3 . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Timp-1high . | Control . | Timp-1low . | Control . | Timp-1high . | Control . | Timp-1low . | Control . | Timp-1high . | Control . | Timp-1low . | Control . |
| Primary tumor | ||||||||||||
| Tumor take | 3/5 | 5/5 | 5/5 | 5/5 | 4/5 | 2/2 | 4/4 | 3/3 | 3/3 | 2/2 | 2/2 | 3/3 |
| Tumors after rechallenge | 0/2 | — | — | — | 0/1 | — | — | — | — | — | — | — |
| DAI to tumor diameter 8.5 mm | 34 | 21 | 16 | 21 | 31 | 20 | 15 | 21 | 33 | 21 | 16 | 22 |
| t50 survival | 45 | 32 | 26 | 32 | 42 | 30 | 26 | 31 | 45 | 31 | 27 | 32 |
| Spontaneous metastasis | ||||||||||||
| Periportal localization | 3/3 | 5/5 | 2/5 | 5/5 | 4/4 | 2/2 | 1/4 | 3/3 | ND | |||
| Diffuse infiltration | 0/3 | 0/5 | 3/5 | 0/5 | 0/4 | 0/2 | 3/4 | 0/3 | ND | |||
In 3 independent experiments, parameters of the primary tumor and spontaneous metastasis were measured in Timp-1high mice, Timp-1low mice, and their respective control littermates.
Abbreviations: DAI, days after tumor cell inoculation; t50, DAI when 50% of the animals are dead; ND, not determined.